{"doi":"10.1096/fj.201701523r","title":"<i>O</i>\n                    ‐GlcNAcylation regulates endoplasmic reticulum exit sites through\n                    <i>Sec31A</i>\n                    modification in conventional secretory pathway","abstract":"<jats:title>ABSTRACT</jats:title>\n                  <jats:p>\n                    The conventional secretory pathway is indispensable for eukaryotic cells. Newly synthesized membrane and secretory proteins are released from the endoplasmic reticulum (ER) through ER‐derived vesicles to their appropriate destination. Vesicle formation is important for steady protein trafficking.\n                    <jats:italic>O</jats:italic>\n                    ‐GlcNAcylation (\n                    <jats:italic>O</jats:italic>\n                    ‐GlcNAc) is a unique protein glycosylation signature, whose dynamic regulation by\n                    <jats:italic>O</jats:italic>\n                    ‐GlcNAc transferase and\n                    <jats:italic>O</jats:italic>\n                    ‐GlcNAcase occurs exclusively for nuclear and cytoplasmic proteins. Because of this locally limited property, the role of\n                    <jats:italic>O</jats:italic>\n                    ‐GlcNAc in the conventional protein secretory pathway is unknown. We report that\n                    <jats:italic>Sec31A</jats:italic>\n                    on COPII vesicles, a specific coat‐protein complex for anterograde trafficking in the ER‐Golgi network, is\n                    <jats:italic>O</jats:italic>\n                    ‐GlcNAcylated on S964, which accelerates COPII vesicle formation through control of its binding affinity to apoptosis‐linked gene 2, a calcium‐binding protein. Together,\n                    <jats:italic>O</jats:italic>\n                    ‐GlcNAc on\n                    <jats:italic>Sec31A</jats:italic>\n                    regulates conventional secretory vesicle trafficking in the ER‐Golgi network. These modifications accelerate COPII vesicle formation and accelerated anterograde transport of vesicles within the ER‐Golgi networks.—Cho, H. J., Mook‐Jung, I.\n                    <jats:italic>O</jats:italic>\n                    ‐GlcNAcylation regulates endoplasmic reticulum exit sites through\n                    <jats:italic>Sec31A</jats:italic>\n                    modification in conventional secretory pathway. FASEB J. 32, 4641–4657 (2018).\n                    <jats:ext-link xmlns:xlink=\"http://www.w3.org/1999/xlink\" xlink:href=\"http://www.fasebj.org\">www.fasebj.org</jats:ext-link>\n                  </jats:p>","journal":"The FASEB Journal","year":2018,"id":30965,"datarank":0.9085139221734535,"base_score":3.1780538303479458,"endowment":3.1780538303479458,"self_citation_contribution":0.47670807455219194,"citation_network_contribution":0.4318058476212616,"self_endowment_contribution":0.47670807455219194,"citer_contribution":0.4318058476212616,"corpus_percentile":null,"corpus_rank":null,"citation_count":23,"citer_count":22,"citers_with_citation_signal":20,"citers_with_endowment":20,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":167029,"name":"Inhee Mook-Jung","orcid":null,"position":1,"is_corresponding":false},{"id":44950,"name":"Hyun Jin Cho","orcid":"0009-0006-8606-0283","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":3.1780538303479458,"endowment":3.1780538303479458,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"29913562","pmcid":null,"openalex_id":"https://openalex.org/W2799760740","authors":[],"funders":[],"total_grants":0,"fwci":0.9276,"citation_percentile":0.73930536,"influential_citations":2,"citation_trend":[{"year":2018,"count":1},{"year":2019,"count":2},{"year":2020,"count":2},{"year":2021,"count":5},{"year":2022,"count":3},{"year":2023,"count":4},{"year":2024,"count":2},{"year":2025,"count":4}],"oa_status":"bronze","license":"http://onlinelibrary.wiley.com/termsAndConditions#vor","oa_locations":[{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1096/fj.201701523R","host_type":"journal"},{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1096/fj.201701523R","host_type":"BRONZE"},{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1096/fj.201701523R","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/pdf/10.1096/fj.201701523R","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/full-xml/10.1096/fj.201701523R","host_type":"publisher"},{"url":"https://faseb.onlinelibrary.wiley.com/doi/pdf/10.1096/fj.201701523R","host_type":"publisher"},{"url":"https://doi.org/10.1096/fj.201701523r","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/29913562","host_type":"repository"}],"fields_of_study":["Glycosylation and Glycoproteins Research","Cellular transport and secretion","Endoplasmic Reticulum Stress and Disease","Biology","Medicine","Chemistry","Apoptosis Regulatory Proteins","Calcium-Binding Proteins","Endoplasmic Reticulum","Golgi Apparatus","Humans","Protein Binding","Protein Transport","Secretory Pathway","Vesicular Transport Proteins"],"mesh_terms":["Calcium-Binding Proteins","Endoplasmic Reticulum","Golgi Apparatus","Humans","Protein Binding","Protein Transport","Vesicular Transport Proteins","Apoptosis Regulatory Proteins","Secretory Pathway"],"keywords":["COPII","Endoplasmic reticulum","Golgi apparatus","Secretory pathway","Cell biology","COPI","Vesicle","Secretory protein","Secretory Vesicle","Secretion","Chemistry","Vesicular Transport Proteins","Cytoplasm","Biology","Biochemistry","Vacuole","Membrane","Transport","Alg-2","Eres","Copii Vesicles","Er–golgi"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-09T06:02:43.010428Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}