{"doi":"10.1094/mpmi-18-0819","title":"β-Aminobutyric Acid-Induced Resistance Against Downy Mildew in Grapevine Acts Through the Potentiation of Callose Formation and Jasmonic Acid Signaling","abstract":"<jats:p> β-Aminobutyric acid (BABA) was used to induce resistance in grapevine, (Vitis vinifera) against downy mildew (Plasmopara viticola). This led to a strong reduction of mycelial growth and sporulation in the susceptible cv. Chasselas. Comparing different inducers, the best protection was achieved with BABA followed by jasmonic acid (JA), whereas benzo (1,2,3)-thiadiazole-7-carbothionic acid-Smethyl ester (a salicylic acid [SA] analog) and abscisic acid (ABA) treatment did not increase the resistance significantly. Marker genes for the SA and JA pathways showed potentiated expression patterns in BABA-treated plants following infection. The callose synthesis inhibitor 2-deoxy- D-glucose partially suppressed BABA- and JA-induced resistance against P. viticola in Chasselas. Application of the phenylalanine ammonia lyase inhibitor 2-aminoindan-2- phosphonic acid and the lipoxygenase (LOX) inhibitor 5, 8, 11, 14-eicosatetraynoic acid (ETYA) also led to a reduction of BABA-induced resistance (BABA-IR), suggesting that callose deposition as well as defense mechanisms depending on phenylpropanoids and the JA pathways all contribute to BABA-IR. The similar phenotype of BABA- and JA-induced resistance, the potentiated expression pattern of JA-regulated genes (LOX-9 and PR-4) following BABA treatment, and the suppression of BABA-IR with ETYA suggest an involvement of the JA pathway in BABA-IR of grapevine leading to a primed deposition of callose and lignin around the infection sites. </jats:p>","journal":"Molecular Plant-Microbe Interactions®","year":2005,"id":22033,"datarank":11.506159122962385,"base_score":5.53338948872752,"endowment":5.53338948872752,"self_citation_contribution":0.8300084233091282,"citation_network_contribution":10.676150699653258,"self_endowment_contribution":0.8300084233091282,"citer_contribution":10.676150699653258,"corpus_percentile":null,"corpus_rank":null,"citation_count":252,"citer_count":200,"citers_with_citation_signal":200,"citers_with_endowment":200,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":139856,"name":"Gabor Jakab","orcid":null,"position":1,"is_corresponding":false},{"id":139857,"name":"Laurent Barnavon","orcid":null,"position":2,"is_corresponding":false},{"id":139858,"name":"Jean-Marc Neuhaus","orcid":null,"position":3,"is_corresponding":false},{"id":139859,"name":"Brigitte Mauch-Mani","orcid":null,"position":4,"is_corresponding":false},{"id":139855,"name":"Mollah Md. Hamiduzzaman","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":5.53338948872752,"endowment":5.53338948872752,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"16134894","pmcid":null,"openalex_id":"https://openalex.org/W2018214496","authors":[],"funders":[],"total_grants":0,"fwci":11.5984,"citation_percentile":0.98352901,"influential_citations":0,"citation_trend":[{"year":2012,"count":20},{"year":2013,"count":27},{"year":2014,"count":15},{"year":2015,"count":15},{"year":2016,"count":9},{"year":2017,"count":4},{"year":2018,"count":4},{"year":2019,"count":18},{"year":2020,"count":10},{"year":2021,"count":11},{"year":2022,"count":10},{"year":2023,"count":12},{"year":2024,"count":9},{"year":2025,"count":9},{"year":2026,"count":4}],"oa_status":"bronze","license":"cc-by-sa","oa_locations":[{"url":"https://apsjournals.apsnet.org/doi/pdf/10.1094/MPMI-18-0819?download=true","host_type":"journal"},{"url":"https://apsjournals.apsnet.org/doi/pdf/10.1094/MPMI-18-0819?download=true","host_type":"publisher"},{"url":"https://apsjournals.apsnet.org/doi/pdf/10.1094/MPMI-18-0819","host_type":"publisher"},{"url":"https://doi.org/10.1094/mpmi-18-0819","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/16134894","host_type":"repository"},{"url":"https://doaj.org/article/b7b3cef37fc94456b46885faadeef3ef","host_type":"repository"}],"fields_of_study":["Plant-Microbe Interactions and Immunity","Plant Parasitism and Resistance","Insect-Plant Interactions and Control","5,8,11,14-Eicosatetraynoic Acid","Abscisic Acid","Aminobutyrates","Cyclopentanes","Fungi","Gene Expression Regulation, Plant","Glucans","Indans","Molecular Sequence Data","Organophosphonates","Oxylipins","Plant Diseases","Plant Growth Regulators","Plant Leaves","Salicylic Acid","Signal Transduction","Sugar Acids","Thiadiazoles","Vitis"],"mesh_terms":["Abscisic Acid","Aminobutyrates","Cyclopentanes","Fungi","Glucans","Indans","Molecular Sequence Data","Plant Diseases","Plant Growth Regulators","Sugar Acids","Thiadiazoles","5,8,11,14-Eicosatetraynoic Acid","Signal Transduction","Gene Expression Regulation, Plant","Plant Leaves","Salicylic Acid","Vitis","Oxylipins","Organophosphonates"],"keywords":["Jasmonic acid","Plasmopara viticola","Callose","Salicylic acid","Downy mildew","Abscisic acid","Biology","Phenylalanine ammonia-lyase","Biochemistry","Plant disease resistance","Microbiology","Botany","Phenylalanine","Gene","Amino acid"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-06T17:40:58.429156Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}