{"doi":"10.1093/trstmh/traa110","title":"Dengue and post-infection fatigue: findings from a prospective cohort—the Colombo Dengue Study","abstract":"BACKGROUND: Previous studies on post-infection fatigue in dengue are few but suggest that up to 25% of dengue patients may suffer from fatigue. This study aimed to evaluate the prevalence and associations of post-infection fatigue in dengue patients compared with non-dengue fever patients. METHODS: Post-infection fatigue and its demographic and clinical associations were assessed in adult dengue and non-dengue fever patients 2 months after the acute infection in a prospective cohort study in Sri Lanka. Fatigue at 2 months (primary endpoint) was assessed with the fatigue questionnaire as a dichotomous outcome based on a pre-recommended cut-off (score ≥4) and as the total score from the questionnaire (higher score indicates more fatigue). RESULTS: Of 260 patients, 158 had dengue and, of these, 51 (32%) had fatigue at 2 months. Risk was higher in dengue patients (vs non-dengue; relative risk [RR] 4.93 [95% confidence interval {CI} 2.3 to 10.4]) and more so in female dengue patients (vs male dengue patients; RR 2.45 [95% CI 1.24 to 4.86]). Severe dengue patients had a higher mean fatigue score (p=0.024). CONCLUSIONS: Post-infection fatigue is an underappreciated burden of this widely prevalent infection. Our findings are useful to triage patients at risk of fatigue for follow-up.","journal":"Transactions of the Royal Society of Tropical Medicine and Hygiene","year":2020,"id":96766,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":34,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.6507,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":479259,"name":"Senaka Rajapakse","orcid":"0000-0003-1965-6678","position":1,"is_corresponding":false},{"id":479260,"name":"Praveen Weeratunga","orcid":"0000-0003-2306-0885","position":2,"is_corresponding":false},{"id":479261,"name":"Nipun Lakshitha de Silva","orcid":"0000-0002-4467-3659","position":3,"is_corresponding":false},{"id":479262,"name":"Laksiri Gomes","orcid":"0000-0002-2336-7919","position":4,"is_corresponding":false},{"id":479263,"name":"Gathsaurie Neelika Malavige","orcid":"0000-0001-9201-0449","position":5,"is_corresponding":false},{"id":479264,"name":"Chaturaka Rodrigo","orcid":"0000-0003-2189-9177","position":6,"is_corresponding":false},{"id":479265,"name":"Sumadhya Deepika Fernando","orcid":"0000-0002-2535-9031","position":7,"is_corresponding":false},{"id":479258,"name":"Chathurani Sigera","orcid":"0000-0001-5263-2219","position":0,"is_corresponding":true}],"reference_count":34,"raw_metadata":null,"created_at":"2026-07-18T22:35:06.014648Z","pmid":"33099653","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}