{"doi":"10.1093/texcom/tgaa023","title":"The Impact of 6 and 12 Months in Space on Human Brain Structure and Intracranial Fluid Shifts","abstract":"= 10 astronauts) missions impact brain structure and fluid shifts. We collected MRI scans once before flight and four times after flight. Astronauts served as their own controls; we evaluated pre- to postflight changes and return toward preflight levels across the 4 postflight points. We also provide data to illustrate typical brain changes over 7 years in a reference dataset. Twelve months in space generally resulted in larger changes across multiple brain areas compared with 6-month missions and aging, particularly for fluid shifts. The majority of changes returned to preflight levels by 6 months after flight. Ventricular volume substantially increased for 1 of the 12-month astronauts (left: +25%, right: +23%) and the 6-month astronauts (left: 17 ± 12%, right: 24 ± 6%) and exhibited little recovery at 6 months. Several changes correlated with past flight experience; those with less time between subsequent missions had larger preflight ventricles and smaller ventricular volume increases with flight. This suggests that spaceflight-induced ventricular changes may endure for long periods after flight. These results provide insight into brain changes that occur with long-duration spaceflight and demonstrate the need for closer study of fluid shifts.","journal":"Cerebral Cortex Communications","year":2020,"id":59230,"datarank":1.5719447671965046,"base_score":4.23410650459726,"endowment":4.23410650459726,"self_citation_contribution":0.635115975689589,"citation_network_contribution":0.9368287915069156,"self_endowment_contribution":0.635115975689589,"citer_contribution":0.9368287915069156,"corpus_percentile":86.82602305252573,"corpus_rank":1704,"citation_count":68,"citer_count":40,"citers_with_citation_signal":29,"citers_with_endowment":29,"datacite_reuse_total":0,"is_dataset":true,"is_dataset_confidence":0.8551,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":311507,"name":"Heather R. McGregor","orcid":"0000-0002-3927-8996","position":1,"is_corresponding":false},{"id":311508,"name":"Jessica Lee","orcid":"0000-0003-1036-2665","position":2,"is_corresponding":false},{"id":313032,"name":"Nichole E. Beltran","orcid":null,"position":3,"is_corresponding":false},{"id":313033,"name":"I. S. Kofman","orcid":null,"position":4,"is_corresponding":false},{"id":313034,"name":"Yiri E. De Dios","orcid":null,"position":5,"is_corresponding":false},{"id":313035,"name":"Patti A Reuter-Lorenz","orcid":null,"position":6,"is_corresponding":false},{"id":311509,"name":"Roy Riascos","orcid":"0000-0002-3081-0413","position":7,"is_corresponding":false},{"id":311510,"name":"Ofer Pasternak","orcid":"0000-0002-7078-6446","position":8,"is_corresponding":false},{"id":311511,"name":"Scott J. Wood","orcid":"0000-0002-2603-7552","position":9,"is_corresponding":false},{"id":311512,"name":"Jacob J. Bloomberg","orcid":"0000-0003-2774-2699","position":10,"is_corresponding":false},{"id":313036,"name":"Ajitkumar P. Mulavara","orcid":null,"position":11,"is_corresponding":false},{"id":311513,"name":"Rachael D. Seidler","orcid":"0000-0003-2452-9024","position":12,"is_corresponding":false},{"id":229339,"name":"Alzheimer’s Disease Neuroimaging Initiative","orcid":null,"position":13,"is_corresponding":false},{"id":311506,"name":"Kathleen E. Hupfeld","orcid":"0000-0001-5086-4841","position":0,"is_corresponding":true}],"reference_count":47,"raw_metadata":null,"created_at":"2026-07-18T21:07:59.189921Z","pmid":"32864615","pmcid":"PMC7446230","fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}