{"doi":"10.1093/tbm/ibac034","title":"Assessment of melanoma precision prevention materials incorporating <i>MC1R</i> genetic risk information","abstract":"Few studies have examined cognitive responses to mailed precision prevention materials. MC1R is a robust, well-described melanoma susceptibility marker. The purpose was to assess cognitive responses to generic or precision prevention materials incorporating MC1R genetic risk. Non-Hispanic White participants (n = 1134) enrolled in a randomized controlled trial received either precision prevention materials incorporating MC1R genetic risk (higher/average) or generic prevention (standard) materials. Six months after baseline, 808 (71.3%) participants reported on the amount of prevention materials read (5-point scale); believability and clarity of materials; intention to change preventive behaviors (7-point Likert scale); and recall of their MC1R genetic risk. Comparisons were conducted using Kruskal-Wallis and chi-squared tests. Overall, participants read most to all (Mdn = 4, IQR = 2) of the prevention materials, reported high believability (Mdn = 7, IQR = 1) and clarity (Mdn = 7, IQR = 1), and moderate intention to change preventive behaviors (Mdn = 5, IQR = 2). Higher-risk participants reported slightly less clarity (Mdn = 6, IQR = 2) than either average-risk (Mdn = 6, IQR = 1, p = 2.50 × 10-3) or standard participants (Mdn = 7, IQR = 1, p = 2.30 × 10-5); and slightly less believability (Mdn = 6, IQR = 1) than standard participants (Mdn = 7, IQR = 1, p = .005). Higher-risk participants were 2.21 times as likely (95% CI = 1.43-3.43) to misremember or forget their risk compared to average-risk participants; misremembering was observed only among higher-risk participants (14%). Mailed precision prevention information were mostly read, highly believable and clear, and resulted in moderate levels of intention to change sun protection behaviors, bolstering the feasibility of population-level precision prevention. Defensive reactions may explain lower clarity, believability, and higher incorrect risk recall among higher-risk participants.","journal":"Translational Behavioral Medicine","year":2022,"id":284932,"datarank":0.3162713388564953,"base_score":1.791759469228055,"endowment":1.791759469228055,"self_citation_contribution":0.26876392038420827,"citation_network_contribution":0.047507418472287004,"self_endowment_contribution":0.26876392038420827,"citer_contribution":0.047507418472287004,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":3,"citers_with_citation_signal":2,"citers_with_endowment":2,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9561,"is_data_producer":true,"deposit_databanks":{"ClinicalTrials.gov":["NCT03509467"]},"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":963576,"name":"Stephanie M. Forgas","orcid":null,"position":1,"is_corresponding":false},{"id":799546,"name":"Scarlet H. Doyle","orcid":null,"position":2,"is_corresponding":false},{"id":521966,"name":"Qian Lü","orcid":"0000-0001-7271-5804","position":3,"is_corresponding":false},{"id":963577,"name":"Jocelyn Del Rio","orcid":null,"position":4,"is_corresponding":false},{"id":963578,"name":"Stella Valavanis","orcid":null,"position":5,"is_corresponding":false},{"id":436530,"name":"Rodrigo Carvajal","orcid":"0000-0002-7607-8272","position":6,"is_corresponding":false},{"id":437211,"name":"Guillermo González-Calderón","orcid":null,"position":7,"is_corresponding":false},{"id":370723,"name":"Youngchul Kim","orcid":"0000-0002-2307-0330","position":8,"is_corresponding":false},{"id":390460,"name":"Richard G. Roetzheim","orcid":"0000-0003-1871-555X","position":9,"is_corresponding":false},{"id":390462,"name":"Susan T. Vadaparampil","orcid":"0000-0002-1052-6917","position":10,"is_corresponding":false},{"id":264813,"name":"Peter A. Kanetsky","orcid":"0000-0002-5567-9618","position":11,"is_corresponding":false},{"id":799045,"name":"John Charles A. Lacson","orcid":"0000-0002-3444-7666","position":0,"is_corresponding":true}],"reference_count":18,"raw_metadata":null,"created_at":"2026-07-19T00:29:40.826853Z","pmid":"35552458","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}