{"doi":"10.1093/stmcls/sxad064","title":"Circulating Osteoprogenitor Cells Have a Mixed Immune and Mesenchymal Progenitor Function in Humans","abstract":"BACKGROUND: Circulating osteoprogenitors (COP) are a population of cells in the peripheral circulation that possess functional and phenotypical characteristics of multipotent stromal cells (MSCs). This population has a solid potential to become an abundant, accessible, and replenishable source of MSCs with multiple potential clinical applications. However, a comprehensive functional characterization of COP cells is still required to test and fully develop their use in clinical settings. METHODS: This study characterized COP cells by comparing them to bone marrow-derived MSCs (BM-MSCs) and adipose-derived MSCs (ASCs) through detailed transcriptomic and proteomic analyses. RESULTS: We demonstrate that COP cells have a distinct gene and protein expression pattern with a significantly stronger immune footprint, likely owing to their hematopoietic lineage. In addition, regarding progenitor cell differentiation and proliferation pathways, COP cells have a similar expression pattern to BM-MSCs and ASCs. CONCLUSION: COP cells are a unique but functionally similar population to BM-MSCs and ASCs, sharing their proliferation and differentiation capacity, thus presenting an accessible source of MSCs with strong potential for translational regenerative medicine strategies.","journal":"Stem Cells","year":2023,"id":365979,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9464,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":653854,"name":"Macsue Jacques","orcid":"0000-0002-4337-7022","position":1,"is_corresponding":false},{"id":352123,"name":"Dmitry Kondrikov","orcid":null,"position":2,"is_corresponding":false},{"id":653860,"name":"Nir Eynon","orcid":"0000-0003-4046-8276","position":3,"is_corresponding":false},{"id":525105,"name":"Tissa Wijeratne","orcid":"0000-0002-1701-7111","position":4,"is_corresponding":false},{"id":1009854,"name":"Vasso Apostolopoulos","orcid":"0000-0001-6788-2771","position":5,"is_corresponding":false},{"id":347836,"name":"Jeffrey M. Gimble","orcid":"0000-0002-4990-7418","position":6,"is_corresponding":false},{"id":874954,"name":"William Hill","orcid":"0000-0002-8033-1605","position":7,"is_corresponding":false},{"id":465766,"name":"Gustavo Duque","orcid":"0000-0001-8126-0637","position":8,"is_corresponding":false},{"id":1009853,"name":"Jack Feehan","orcid":"0000-0002-9627-1299","position":0,"is_corresponding":true}],"reference_count":89,"raw_metadata":null,"created_at":"2026-07-19T01:14:50.885797Z","pmid":"37609930","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}