{"doi":"10.1093/stmcls/sxad034","title":"Loss of LRP1 in Adult Neural Stem Cells Impairs Migration to Ischemic Lesions","abstract":"After ischemia, cells in the brain parenchyma upregulate stromal derived factor 1 (SDF1), driving chemokine receptor CXCR4-mediated migration of adult neural stem cells to the ischemic injury. We discovered a novel regulator of CXCR4 in neural stem cells, low-density lipoprotein receptor related protein 1 (LRP1). We used Nestin-driven knockout of LRP1 and induction of td-tomato in neural stem cells of adult mice. We observed reduced localization of td-tomato positive cells to the lesion, and find disrupted CXCR4-mediated neural stem cell migration in vitro, which is likely driven by LRP1-mediated loss of CXCR4 expression in vivo. Our results suggest that LRP1 is a novel regulator of CXCR4 in neural stem cells. This heretofore unknown interaction between LRP1 and CXCR4 could have significant consequences for multiple aspects of neural stem cell physiology.","journal":"Stem Cells","year":2023,"id":380179,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9554,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1007099,"name":"Swetha Mahesula","orcid":null,"position":1,"is_corresponding":false},{"id":1007100,"name":"Sheetal Hegde","orcid":null,"position":2,"is_corresponding":false},{"id":1007101,"name":"John Verschelde","orcid":null,"position":3,"is_corresponding":false},{"id":189031,"name":"Pamela Reed","orcid":null,"position":4,"is_corresponding":false},{"id":714698,"name":"Shane Sprague","orcid":null,"position":5,"is_corresponding":false},{"id":269440,"name":"Erzsebet Kokovay","orcid":null,"position":6,"is_corresponding":false},{"id":665309,"name":"N. Sayre","orcid":"0000-0002-6124-2535","position":7,"is_corresponding":false},{"id":1006726,"name":"Kristi Dietert","orcid":"0000-0003-2338-7968","position":0,"is_corresponding":true}],"reference_count":29,"raw_metadata":null,"created_at":"2026-07-19T01:17:00.789848Z","pmid":"37186298","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}