{"doi":"10.1093/stcltm/szad078","title":"Cell Therapy Improves Quality-of-Life in Heart Failure: Outcomes From a Phase III Clinical Trial","abstract":"Patients with heart failure experience limitations in daily activity and poor quality-of-life. Prospective surveillance of health-related quality-of-life supplemented traditional death and hospitalization outcomes in the multinational, randomized, double-blinded CHART-1 clinical trial that assessed cardiopoiesis-guided cell therapy in ischemic heart failure patients with reduced left ventricular ejection fraction. The Minnesota Living with Heart Failure Questionnaire (MLHFQ), a Food and Drug Administration qualified instrument for evaluating therapeutic effectiveness, was applied through the 1-year follow-up. Cell treated (n = 109) and sham procedure (n = 140) cohorts reported improved MLHFQ scores comparable between the 2 study arms (mean treatment difference with baseline adjustment -3.2 points, P = .107). Superiority of cell treatment over sham in betterment of the MLHFQ score was demonstrated in patients with pre-existing advanced left ventricular enlargement (baseline-adjusted mean treatment difference -6.4 points, P = .009). In this highly responsive subpopulation, benefit on the MLHFQ score paralleled reduction in death and hospitalization post-cell therapy (adjusted Mann-Whitney odds 1.43, 95% CI, 1.01-2.01; P = .039). The potential of cell therapy in addressing the quality-of-life dimension of heart failure requires further evaluation for disease relief.","journal":"Stem Cells Translational Medicine","year":2023,"id":371866,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9491,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":764792,"name":"Jozef Bartúnek","orcid":"0000-0002-4927-1632","position":1,"is_corresponding":false},{"id":1131899,"name":"Thomas J. Povsic","orcid":"0000-0002-0573-6565","position":2,"is_corresponding":false},{"id":507053,"name":"Gad Cotter","orcid":"0000-0002-9613-3339","position":3,"is_corresponding":false},{"id":507054,"name":"Beth A. Davison","orcid":"0000-0003-2374-6449","position":4,"is_corresponding":false},{"id":800074,"name":"Christopher Edwards","orcid":"0000-0003-4908-9758","position":5,"is_corresponding":false},{"id":392085,"name":"Atta Behfar","orcid":"0000-0003-3775-5784","position":6,"is_corresponding":false},{"id":49608,"name":"Marco Metra","orcid":"0000-0001-6691-8568","position":7,"is_corresponding":false},{"id":58220,"name":"Gerasimos Filippatos","orcid":"0000-0002-5640-0332","position":8,"is_corresponding":false},{"id":1083563,"name":"Marc Vanderheyden","orcid":"0000-0003-3050-5221","position":9,"is_corresponding":false},{"id":72500,"name":"William Wijns","orcid":"0000-0002-7267-4376","position":10,"is_corresponding":false},{"id":3672,"name":"André Terzic","orcid":"0000-0001-9210-009X","position":11,"is_corresponding":false},{"id":392084,"name":"Satsuki Yamada","orcid":"0000-0003-3072-4539","position":0,"is_corresponding":true}],"reference_count":74,"raw_metadata":null,"created_at":"2026-07-19T01:15:49.453761Z","pmid":"38006196","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}