{"doi":"10.1093/sleep/zsae125","title":"Associations between longitudinal changes in sleep stages and risk of cognitive decline in older men","abstract":"STUDY OBJECTIVES: To investigate the relationships between longitudinal changes in sleep stages and the risk of cognitive decline in older men. METHODS: This study included 978 community-dwelling older men who participated in the first (2003-2005) and second (2009-2012) sleep ancillary study visits of the Osteoporotic Fractures in Men Study. We examined the longitudinal changes in sleep stages at the initial and follow-up visits, and the association with concurrent clinically relevant cognitive decline during the 6.5-year follow-up. RESULTS: Men with low to moderate (quartile 2, Q2) and moderate increase (Q3) in N1 sleep percentage had a reduced risk of cognitive decline on the modified mini-mental state examination compared to those with a substantial increase (Q4) in N1 sleep percentage. Additionally, men who experienced a low to moderate (Q2) increase in N1 sleep percentage had a lower risk of cognitive decline on the Trails B compared with men in the reference group (Q4). Furthermore, men with the most pronounced reduction (Q1) in N2 sleep percentage had a significantly higher risk of cognitive decline on the Trails B compared to those in the reference group (Q4). No significant association was found between changes in N3 and rapid eye movement sleep and the risk of cognitive decline. CONCLUSIONS: Our results suggested that a relatively lower increase in N1 sleep showed a reduced risk of cognitive decline. However, a pronounced decrease in N2 sleep was associated with concurrent cognitive decline. These findings may help identify older men at risk of clinically relevant cognitive decline.","journal":"SLEEP","year":2024,"id":475174,"datarank":0.24141568686511508,"base_score":1.6094379124341003,"endowment":1.6094379124341003,"self_citation_contribution":0.24141568686511508,"citation_network_contribution":0.0,"self_endowment_contribution":0.24141568686511508,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.6258,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":245151,"name":"Katie L. Stone","orcid":"0000-0003-2797-3171","position":1,"is_corresponding":false},{"id":1311993,"name":"Zheng-An Lu","orcid":"0000-0002-8379-3952","position":2,"is_corresponding":false},{"id":1312328,"name":"Shanshan Tian","orcid":null,"position":3,"is_corresponding":false},{"id":1311994,"name":"Yongbo Zheng","orcid":"0000-0002-5314-5364","position":4,"is_corresponding":false},{"id":559389,"name":"Bingxin Zhao","orcid":"0000-0002-0979-7891","position":5,"is_corresponding":false},{"id":316918,"name":"Yanping Bao","orcid":"0000-0002-1881-0939","position":6,"is_corresponding":false},{"id":1311995,"name":"Le Shi","orcid":"0000-0003-4827-4003","position":7,"is_corresponding":false},{"id":316919,"name":"Lin Lü","orcid":"0000-0003-0742-9072","position":8,"is_corresponding":false},{"id":1311992,"name":"Qianwen Wang","orcid":"0009-0008-5251-9353","position":0,"is_corresponding":true}],"reference_count":68,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T02:06:16.992586Z","pmid":"38829819","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}