{"doi":"10.1093/sleep/zsad312","title":"Associations between actigraphy-measured sleep duration, continuity, and timing with mortality in the UK Biobank","abstract":"STUDY OBJECTIVES: To examine the associations between sleep duration, continuity, timing, and mortality using actigraphy among adults. METHODS: Data were from a cohort of 88 282 adults (40-69 years) in UK Biobank that wore a wrist-worn triaxial accelerometer for 7 days. Actigraphy data were processed to generate estimates of sleep duration and other sleep characteristics including wake after sleep onset (WASO), number of 5-minute awakenings, and midpoint for sleep onset/wake-up and the least active 5 hours (L5). Data were linked to mortality outcomes with follow-up to October 31, 2021. We implemented Cox models (hazard ratio, confidence intervals [HR, 95% CI]) to quantify sleep associations with mortality. Models were adjusted for demographics, lifestyle factors, and medical conditions. RESULTS: Over an average of 6.8 years 2973 deaths occurred (1700 cancer, 586 CVD deaths). Overall sleep duration was significantly associated with risk for all-cause (p < 0.01), cancer (p < 0.01), and CVD (p = 0.03) mortality. For example, when compared to sleep durations of 7.0 hrs/d, durations of 5 hrs/d were associated with a 29% higher risk for all-cause mortality (HR: 1.29 [1.09, 1.52]). WASO and number of awakenings were not associated with mortality. Individuals with L5 early or late midpoints (<2:30 or ≥ 3:30) had a ~20% higher risk for all-cause mortality, compared to those with intermediate L5 midpoints (3:00-3:29; p ≤ 0.01; e.g. HR ≥ 3:30: 1.19 [1.07, 1.32]). CONCLUSIONS: Shorter sleep duration and both early and late sleep timing were associated with a higher mortality risk. These findings reinforce the importance of public health efforts to promote healthy sleep patterns in adults.","journal":"SLEEP","year":2023,"id":327865,"datarank":0.9968158184463725,"base_score":3.258096538021482,"endowment":3.258096538021482,"self_citation_contribution":0.4887144807032224,"citation_network_contribution":0.50810133774315,"self_endowment_contribution":0.4887144807032224,"citer_contribution":0.50810133774315,"corpus_percentile":79.60857120755009,"corpus_rank":2637,"citation_count":25,"citer_count":24,"citers_with_citation_signal":17,"citers_with_endowment":17,"datacite_reuse_total":0,"is_dataset":true,"is_dataset_confidence":0.6833,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":475166,"name":"Joshua R. Freeman","orcid":"0000-0001-7483-7848","position":1,"is_corresponding":false},{"id":620309,"name":"D. Russ","orcid":"0000-0003-4040-4416","position":2,"is_corresponding":false},{"id":272280,"name":"Jonas S. Almeida","orcid":"0000-0002-7883-7922","position":3,"is_corresponding":false},{"id":737000,"name":"Marissa Shams‐White","orcid":"0000-0002-7824-4545","position":4,"is_corresponding":false},{"id":318426,"name":"Shreya Patel","orcid":"0000-0002-0105-1841","position":5,"is_corresponding":false},{"id":630862,"name":"Dana L. Wolff‐Hughes","orcid":"0000-0003-3280-9771","position":6,"is_corresponding":false},{"id":557727,"name":"Eleanor L. Watts","orcid":"0000-0001-9229-2589","position":7,"is_corresponding":false},{"id":275427,"name":"Erikka Loftfield","orcid":"0000-0002-3573-8748","position":8,"is_corresponding":false},{"id":447964,"name":"Hyokyoung G. Hong","orcid":"0000-0002-4280-6243","position":9,"is_corresponding":false},{"id":348016,"name":"Steven C. Moore","orcid":"0000-0002-8169-1661","position":10,"is_corresponding":false},{"id":231465,"name":"Charles E. Matthews","orcid":"0000-0001-8037-3103","position":11,"is_corresponding":false},{"id":318427,"name":"Pedro F. Saint‐Maurice","orcid":"0000-0002-8752-2340","position":0,"is_corresponding":true}],"reference_count":52,"raw_metadata":null,"created_at":"2026-07-19T01:08:47.581262Z","pmid":"38066693","pmcid":"PMC10925955","fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}