{"doi":"10.1093/sleep/zsaa135","title":"Impact of evening alcohol consumption on nocturnal autonomic and cardiovascular function in adult men and women: a dose–response laboratory investigation","abstract":"STUDY OBJECTIVES: To investigate the dose-dependent impact of moderate alcohol intake on sleep-related cardiovascular (CV) function, in adult men and women. METHODS: A total of 26 healthy adults (30-60 years; 11 women) underwent 3 nights of laboratory polysomnographic (PSG) recordings in which different doses of alcohol (low: 1 standard drink for women and 2 drinks for men; high: 3 standard drinks for women and 4 drinks for men; placebo: no alcohol) were administered in counterbalanced order before bedtime. These led to bedtime average breath alcohol levels of up to 0.02% for the low doses and around 0.05% for the high doses. Autonomic and CV function were evaluated using electrocardiography, impedance cardiography, and beat-to-beat blood pressure monitoring. RESULTS: Presleep alcohol ingestion resulted in an overall increase in nocturnal heart rate (HR), suppressed total and high-frequency (vagal) HR variability, reduced baroreflex sensitivity, and increased sympathetic activity, with effects pronounced after high-dose alcohol ingestion (p's < 0.05); these changes followed different dose- and measure-dependent nocturnal patterns in men and women. Systolic blood pressure showed greater increases during the morning hours of the high-alcohol dose night compared to the low-alcohol dose night and placebo, in women only (p's < 0.05). CONCLUSIONS: Acute evening alcohol consumption, even at moderate doses, has marked dose- and time-dependent effects on sleep CV regulation in adult men and women. Further studies are needed to evaluate the potential CV risk of repeated alcohol-related alterations in nighttime CV restoration in healthy individuals and in those at high risk for CV diseases, considering sex and alcohol dose and time effects.","journal":"SLEEP","year":2020,"id":79572,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":16,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.7975,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":413448,"name":"Mohamad Forouzanfar","orcid":"0000-0001-8849-0144","position":1,"is_corresponding":false},{"id":265803,"name":"Harold S. Javitz","orcid":"0000-0002-6370-174X","position":2,"is_corresponding":false},{"id":265802,"name":"Aimée Goldstone","orcid":"0000-0003-2459-4790","position":3,"is_corresponding":false},{"id":268974,"name":"Stephanie Claudatos","orcid":null,"position":4,"is_corresponding":false},{"id":414789,"name":"Vanessa Alschuler","orcid":null,"position":5,"is_corresponding":false},{"id":240033,"name":"Fiona C. Baker","orcid":"0000-0001-9602-6165","position":6,"is_corresponding":false},{"id":198818,"name":"Ian M. Colrain","orcid":null,"position":7,"is_corresponding":false},{"id":265806,"name":"Massimiliano de Zambotti","orcid":"0000-0002-0057-5977","position":0,"is_corresponding":true}],"reference_count":70,"raw_metadata":null,"created_at":"2026-07-18T21:50:57.971597Z","pmid":"32663278","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}