{"doi":"10.1093/sleep/zsaa006","title":"Alterations in sleep electroencephalography synchrony in combat-exposed veterans with post-traumatic stress disorder","abstract":"STUDY OBJECTIVES: We assessed whether the synchrony between brain regions, analyzed using electroencephalography (EEG) signals recorded during sleep, is altered in subjects with post-traumatic stress disorder (PTSD) and whether the results are reproducible across consecutive nights and subpopulations of the study. METHODS: A total of 78 combat-exposed veteran men with (n = 31) and without (n = 47) PTSD completed two consecutive laboratory nights of high-density EEG recordings. We computed a measure of synchrony for each EEG channel-pair across three sleep stages (rapid eye movement [REM] and non-REM stages 2 and 3) and six frequency bands. We examined the median synchrony in 9 region-of-interest (ROI) pairs consisting of 6 bilateral brain regions (left and right frontal, central, and parietal regions) for 10 frequency-band and sleep-stage combinations. To assess reproducibility, we used the first 47 consecutive subjects (18 with PTSD) for initial discovery and the remaining 31 subjects (13 with PTSD) for replication. RESULTS: In the discovery analysis, five alpha-band synchrony pairs during non-REM sleep were consistently larger in PTSD subjects compared with controls (effect sizes ranging from 0.52 to 1.44) across consecutive nights: two between the left-frontal and left-parietal ROIs, one between the left-central and left-parietal ROIs, and two across central and parietal bilateral ROIs. These trends were preserved in the replication set. CONCLUSION: PTSD subjects showed increased alpha-band synchrony during non-REM sleep in the left frontoparietal, left centro-parietal, and inter-parietal brain regions. Importantly, these trends were reproducible across consecutive nights and subpopulations. Thus, these alterations in alpha synchrony may be discriminatory of PTSD.","journal":"SLEEP","year":2020,"id":83914,"datarank":0.5928235842538276,"base_score":2.3978952727983707,"endowment":2.3978952727983707,"self_citation_contribution":0.3596842909197557,"citation_network_contribution":0.233139293334072,"self_endowment_contribution":0.3596842909197557,"citer_contribution":0.233139293334072,"corpus_percentile":66.75175988241665,"corpus_rank":4299,"citation_count":10,"citer_count":7,"citers_with_citation_signal":7,"citers_with_endowment":7,"datacite_reuse_total":0,"is_dataset":true,"is_dataset_confidence":0.5813,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":430965,"name":"Chao Wang","orcid":"0000-0003-3192-2780","position":1,"is_corresponding":false},{"id":430966,"name":"Sridhar Ramakrishnan","orcid":"0000-0002-7958-1244","position":2,"is_corresponding":false},{"id":431581,"name":"Tatsuya Oyama","orcid":null,"position":3,"is_corresponding":false},{"id":431582,"name":"J. David Cashmere","orcid":null,"position":4,"is_corresponding":false},{"id":326833,"name":"Anne Germain","orcid":"0000-0001-6672-4800","position":5,"is_corresponding":false},{"id":430967,"name":"Jaques Reifman","orcid":"0000-0001-7292-2029","position":6,"is_corresponding":false},{"id":430964,"name":"S. Laxminarayan","orcid":"0000-0002-5696-9705","position":0,"is_corresponding":true}],"reference_count":53,"raw_metadata":null,"created_at":"2026-07-18T21:54:32.422022Z","pmid":"31971594","pmcid":"PMC8240478","fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}