{"doi":"10.1093/pubmed/fdac118","title":"The association of new-onset diabetes with subsequent diagnosis of pancreatic cancer—novel use of a large administrative database","abstract":"BACKGROUND: Screening options for pancreatic ductal adenocarcinoma (PDAC) are limited. New-onset type 2 diabetes (NoD) is associated with subsequent diagnosis of PDAC in observational studies and may afford an opportunity for PDAC screening. We evaluated this association using a large administrative database. METHODS: Patients were identified using claims data from the OptumLabs® Data Warehouse. Adult patients with NoD diagnosis were matched 1:3 with patients without NoD using age, sex and chronic obstructive pulmonary disease (COPD) status. The event of PDAC diagnosis was compared between cohorts using the Kaplan-Meier method. Factors associated with PDAC diagnosis were evaluated with Cox's proportional hazards modeling. RESULTS: We identified 640 421 patients with NoD and included 1 921 263 controls. At 3 years, significantly more PDAC events were identified in the NoD group vs control group (579 vs 505; P < 0.001). When controlling for patient factors, NoD was significantly associated with elevated risk of PDAC (HR 3.474, 95% CI 3.082-3.920, P < 0.001). Other factors significantly associated with PDAC diagnosis were increasing age, increasing age among Black patients, and COPD diagnosis (P ≤ 0.05). CONCLUSIONS: NoD was independently associated with subsequent diagnosis of PDAC within 3 years. Future studies should evaluate the feasibility and benefit of PDAC screening in patients with NoD.","journal":"Journal of Public Health","year":2022,"id":265448,"datarank":0.5101374508966559,"base_score":2.4849066497880004,"endowment":2.4849066497880004,"self_citation_contribution":0.37273599746820013,"citation_network_contribution":0.13740145342845572,"self_endowment_contribution":0.37273599746820013,"citer_contribution":0.13740145342845572,"corpus_percentile":62.21087646012222,"corpus_rank":4886,"citation_count":11,"citer_count":11,"citers_with_citation_signal":8,"citers_with_endowment":8,"datacite_reuse_total":0,"is_dataset":true,"is_dataset_confidence":0.5205,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":924525,"name":"Adam Sheka","orcid":"0000-0001-9081-7249","position":1,"is_corresponding":false},{"id":650912,"name":"Christopher J. LaRocca","orcid":"0000-0002-9808-1405","position":2,"is_corresponding":false},{"id":925092,"name":"R L Irey","orcid":null,"position":3,"is_corresponding":false},{"id":3622,"name":"Sai Ma","orcid":"0000-0002-9785-7929","position":4,"is_corresponding":false},{"id":517646,"name":"Keith M. Wirth","orcid":"0000-0002-0621-5761","position":5,"is_corresponding":false},{"id":925093,"name":"A Benner","orcid":null,"position":6,"is_corresponding":false},{"id":517648,"name":"Jason W. Denbo","orcid":"0000-0002-3973-1738","position":7,"is_corresponding":false},{"id":421959,"name":"Eric H. Jensen","orcid":"0000-0001-8016-757X","position":8,"is_corresponding":false},{"id":421953,"name":"Jacob S. Ankeny","orcid":"0000-0002-4595-8592","position":9,"is_corresponding":false},{"id":725568,"name":"Sayeed Ikramuddin","orcid":"0000-0003-3088-7952","position":10,"is_corresponding":false},{"id":517647,"name":"Todd M. Tuttle","orcid":"0000-0001-6603-2062","position":11,"is_corresponding":false},{"id":242418,"name":"Jane Yuet Ching Hui","orcid":"0000-0002-2628-0720","position":12,"is_corresponding":false},{"id":374775,"name":"Schelomo Marmor","orcid":"0000-0003-0880-2721","position":13,"is_corresponding":false},{"id":925091,"name":"Mary Jane White","orcid":null,"position":0,"is_corresponding":true}],"reference_count":48,"raw_metadata":null,"created_at":"2026-07-19T00:26:49.862989Z","pmid":"36321614","pmcid":"PMC10273390","fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}