{"doi":"10.1093/pnasnexus/pgad247","title":"Maternal-derived galectin-1 shapes the placenta niche through Sda terminal glycosylation: Implication for preeclampsia","abstract":"Placental abnormalities cause impaired fetal growth and poor pregnancy outcome (e.g. preeclampsia [PE]) with long-lasting consequences for the mother and offspring. The molecular dialogue between the maternal niche and the developing placenta is critical for the function of this organ. Galectin-1 (gal-1), a highly expressed glycan-binding protein at the maternal-fetal interface, orchestrates the maternal adaptation to pregnancy and placenta development. Down-regulation or deficiency of gal-1 during pregnancy is associated with the development of PE; however, the maternal- and placental-derived gal-1 contributions to the disease onset are largely unknown. We demonstrate that lack of gal-1 imposes a risk for PE development in a niche-specific manner, and this is accompanied by a placental dysfunction highly influenced by the absence of maternal-derived gal-1. Notably, differential placental glycosylation through the Sda-capped N-glycans dominates the invasive trophoblast capacity triggered by maternal-derived gal-1. Our findings show that gal-1 derived from the maternal niche is essential for healthy placenta development and indicate that impairment of the gal-1 signaling pathway within the maternal niche could be a molecular cause for maternal cardiovascular maladaptation during pregnancy.","journal":"PNAS Nexus","year":2023,"id":344763,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":13,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9467,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1083651,"name":"Fangqi Zhao","orcid":"0000-0001-8692-9424","position":1,"is_corresponding":false},{"id":1078101,"name":"Nancy Freitag","orcid":"0000-0001-5972-1863","position":2,"is_corresponding":false},{"id":1083652,"name":"Sophia Borowski","orcid":"0000-0002-9972-8389","position":3,"is_corresponding":false},{"id":545589,"name":"Yiru Wang","orcid":"0009-0006-2193-6686","position":4,"is_corresponding":false},{"id":1083653,"name":"Charlotte Harms","orcid":"0000-0002-5105-4020","position":5,"is_corresponding":false},{"id":1084154,"name":"Poh‐Choo Pang","orcid":null,"position":6,"is_corresponding":false},{"id":1083654,"name":"Juliette Desforges","orcid":"0000-0002-7014-4590","position":7,"is_corresponding":false},{"id":1083655,"name":"Tianyu Wen","orcid":"0000-0002-5780-5833","position":8,"is_corresponding":false},{"id":362177,"name":"Edzard Schwedhelm","orcid":"0000-0003-3597-6276","position":9,"is_corresponding":false},{"id":237467,"name":"Manvendra Singh","orcid":"0000-0002-8626-5418","position":10,"is_corresponding":false},{"id":462025,"name":"Ralf Dechend","orcid":"0000-0001-6636-3080","position":11,"is_corresponding":false},{"id":471337,"name":"Anne Dell","orcid":"0000-0003-1380-2347","position":12,"is_corresponding":false},{"id":288040,"name":"Stuart M. Haslam","orcid":"0000-0002-5563-679X","position":13,"is_corresponding":false},{"id":363363,"name":"Gabriela Dveksler","orcid":"0000-0003-3037-1155","position":14,"is_corresponding":false},{"id":498007,"name":"Mariana Garcı́a","orcid":"0000-0001-8999-5347","position":15,"is_corresponding":false},{"id":493763,"name":"Sandra M. Blois","orcid":"0000-0002-0434-2660","position":16,"is_corresponding":false},{"id":1083650,"name":"Yiran Xie","orcid":"0000-0001-5858-9637","position":0,"is_corresponding":true}],"reference_count":67,"raw_metadata":null,"created_at":"2026-07-19T01:11:35.133818Z","pmid":"37575671","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}