{"doi":"10.1093/pm/pnae097","title":"Introduction: Pain Management Collaboratory: updates, lessons learned, and future directions","abstract":"Since its launch in 2017, the Pain Management Collaboratory (PMC) has emerged as an important resource for the field of pain management. A strong and growing multidisciplinary PMC community consists of clinical pain scientists; methodologists; sponsors of clinical pain research; persons with lived experience of pain, especially military service members and their dependents and military veterans; and policy and practice leaders, particularly those from the Veterans Health Administration (VHA) and Defense Health Agency (DHA). The PMC is recognized as a highly significant and innovative tri-government agency partnership and investment involving the National Institutes of Health and the Departments of Defense and Veterans Affairs that addresses the gap between evidence of the effectiveness of integrated models of pain care that incorporate nonpharmacological approaches, including complementary and integrative health approaches, and the uptake of these models of care and approaches in routine clinical care. The PMC can highlight significant contributions to the scientific and scholarly literature, as well as contributions that have helped inform major clinical practice and policy initiatives in the VHA and DHA. To date, Collaboratory investigators, in partnership with patients and organizational leaders, have contributed more than 70 original, peer-reviewed publications in leading journals, including articles reporting on lessons learned, best practices, and related innovations for improving the science of pragmatic clinical trials (PCTs) and related topics and for optimizing integrated, evidence-based pain care. A diverse group of more than 11 000 recipients of care in the VHA and DHA have benefited from participation in the 11 originally funded PCTs examining the effectiveness of evidence-based nonpharmacological approaches for the management of pain and co-occurring conditions when delivered in real-world clinical settings. A robust website (www.painmanagementcollaboratory.org) continues to mature to promote access to information about the Collaboratory and about nonpharmacological approaches and integrated models of pain care. As the original PCTs complete their data collection and planned analyses, the Collaboratory is increasingly focused on promoting sustainment of effective interventions in the clinical settings in which the trials were enacted and broader implementation in the VHA and DHA. Overall, the PMC will continue to address previously noted scientific knowledge and clinical practice gaps that spurred research leaders from the National Institutes of Health, particularly the National Center for Complementary and Integrative Health, to partner with VHA and DHA research programs to support this important initiative. In the fall of 2020, the PMC partnered with the journal Pain Medicine to publish a supplement that included the design of the originally funded Collaboratory PCTs, complemented by editorials and related commentaries.1 The present supplement is designed to continue to disseminate updates, lessons learned, and best practices from the Collaboratory to inform future PCTs, as well as major VHA and DHA policy and practice initiatives. Complementing this introductory editorial, the supplement includes a second editorial from senior policy and practice leaders in the VHA and DHA highlighting the significance of the Collaboratory in informing continued efforts to fulfill the vision of these organizations’ Stepped Care Model of Pain Management and initiatives to promote objectives of their respective Whole Health initiatives.2 These editorials offer a framework for considering the remaining articles that comprise this supplement, including descriptions of protocols for two recently funded PCTs that are now included in the PMC portfolio of projects. The PMC has prioritized initiatives and activities designed to optimize its scientific and clinical impact. From the earliest days, a key mantra has been to ensure that the","journal":"Pain Medicine","year":2024,"id":482132,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.6857,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":263472,"name":"Cynthia Brandt","orcid":"0000-0001-8179-1796","position":1,"is_corresponding":false},{"id":98374,"name":"Peter Peduzzi","orcid":"0000-0002-7634-6804","position":2,"is_corresponding":false},{"id":431791,"name":"Robert D. Kerns","orcid":"0000-0002-3834-973X","position":0,"is_corresponding":true}],"reference_count":35,"raw_metadata":null,"created_at":"2026-07-19T02:07:14.349221Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}