{"doi":"10.1093/plphys/kiac480","title":"Variation in plant Toll/Interleukin-1 receptor domain protein dependence on <i>ENHANCED DISEASE SUSCEPTIBILITY 1</i>","abstract":"Toll/Interleukin-1 receptor (TIR) domains are integral to immune systems across all kingdoms. In plants, TIRs are present in nucleotide-binding leucine-rich repeat (NLR) immune receptors, NLR-like, and TIR-only proteins. Although TIR-NLR and TIR signaling in plants require the ENHANCED DISEASE SUSCEPTIBILITY 1 (EDS1) protein family, TIRs persist in species that have no EDS1 members. To assess whether particular TIR groups evolved with EDS1, we searched for TIR-EDS1 co-occurrence patterns. Using a large-scale phylogenetic analysis of TIR domains from 39 algal and land plant species, we identified 4 TIR families that are shared by several plant orders. One group occurred in TIR-NLRs of eudicots and another in TIR-NLRs across eudicots and magnoliids. Two further groups were more widespread. A conserved TIR-only group co-occurred with EDS1 and members of this group elicit EDS1-dependent cell death. In contrast, a maize (Zea mays) representative of TIR proteins with tetratricopeptide repeats was also present in species without EDS1 and induced EDS1-independent cell death. Our data provide a phylogeny-based plant TIR classification and identify TIRs that appear to have evolved with and are dependent on EDS1, while others have EDS1-independent activity.","journal":"PLANT PHYSIOLOGY","year":2022,"id":241348,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":42,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9547,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":615097,"name":"Erin Baggs","orcid":"0000-0003-3076-9489","position":1,"is_corresponding":false},{"id":870193,"name":"Charles Uhlmann","orcid":"0000-0002-6749-4805","position":2,"is_corresponding":false},{"id":870194,"name":"Federica Locci","orcid":"0000-0001-5443-0717","position":3,"is_corresponding":false},{"id":870195,"name":"Henriette L. Läßle","orcid":"0000-0002-1940-3745","position":4,"is_corresponding":false},{"id":870196,"name":"Katharina Melkonian","orcid":"0000-0001-7627-0953","position":5,"is_corresponding":false},{"id":870708,"name":"Kiara Käufer","orcid":null,"position":6,"is_corresponding":false},{"id":870197,"name":"Joram A. Dongus","orcid":"0000-0002-8553-6802","position":7,"is_corresponding":false},{"id":700682,"name":"Hirofumi Nakagami","orcid":"0000-0003-2569-7062","position":8,"is_corresponding":false},{"id":14610,"name":"Ksenia V. Krasileva","orcid":"0000-0002-1679-0700","position":9,"is_corresponding":false},{"id":74950,"name":"Jane E. Parker","orcid":"0000-0002-4700-6480","position":10,"is_corresponding":false},{"id":648562,"name":"Dmitry Lapin","orcid":"0000-0001-9591-3950","position":11,"is_corresponding":false},{"id":858056,"name":"Oliver Johanndrees","orcid":"0000-0001-6659-3951","position":0,"is_corresponding":true}],"reference_count":94,"raw_metadata":null,"created_at":"2026-07-19T00:22:56.227656Z","pmid":"36227084","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}