{"doi":"10.1093/plphys/kiab435","title":"Myosin XI drives polarized growth by vesicle focusing and local enrichment of F-actin in <i>Physcomitrium patens</i>","abstract":"In tip-growing plant cells, growth results from myosin XI and F-actin-mediated deposition of cell wall polysaccharides contained in secretory vesicles. Previous evidence showed that myosin XI anticipates F-actin accumulation at the cell's tip, suggesting a mechanism where vesicle clustering via myosin XI increases F-actin polymerization. To evaluate this model, we used a conditional loss-of-function strategy by generating moss (Physcomitrium patens) plants harboring a myosin XI temperature-sensitive allele. We found that loss of myosin XI function alters tip cell morphology, vacuolar homeostasis, and cell viability but not following F-actin depolymerization. Importantly, our conditional loss-of-function analysis shows that myosin XI focuses and directs vesicles at the tip of the cell, which induces formin-dependent F-actin polymerization, increasing F-actin's local concentration. Our findings support the role of myosin XI in vesicle focusing, possibly via clustering and F-actin organization, necessary for tip growth, and deepen our understanding of additional myosin XI functions.","journal":"PLANT PHYSIOLOGY","year":2021,"id":199444,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":9,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9599,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":365073,"name":"Pattipong Wisanpitayakorn","orcid":"0000-0001-9331-0590","position":1,"is_corresponding":false},{"id":308719,"name":"Jeffrey P. Bibeau","orcid":"0000-0001-6944-9138","position":2,"is_corresponding":false},{"id":775932,"name":"Yen-Chun Liu","orcid":"0000-0001-9661-8531","position":3,"is_corresponding":false},{"id":365423,"name":"Fabienne Furt","orcid":null,"position":4,"is_corresponding":false},{"id":776549,"name":"Ellen Christine Pierce","orcid":null,"position":5,"is_corresponding":false},{"id":776550,"name":"Parker J. Simpson","orcid":null,"position":6,"is_corresponding":false},{"id":365076,"name":"Erkan Tüzel","orcid":"0000-0002-1337-9932","position":7,"is_corresponding":false},{"id":363947,"name":"Luis Vidali","orcid":"0000-0002-5835-4587","position":8,"is_corresponding":false},{"id":389588,"name":"Giulia Galotto","orcid":null,"position":0,"is_corresponding":true}],"reference_count":61,"raw_metadata":null,"created_at":"2026-07-18T23:50:40.558460Z","pmid":"34890463","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}