{"doi":"10.1093/oncolo/oyad162","title":"Avelumab in Patients With Metastatic Colorectal Cancer","abstract":"BACKGROUND: Metastatic colorectal cancer (mCRC) is incurable, and median overall survival is less than 2½ years. Although monoclonal antibodies that block PD-1/PD-L1 interactions are active in microsatellite unstable/mismatch repair deficient tumors, a growing dataset shows that most patients with microsatellite stable/mismatch repair proficient tumors will not benefit from the blockade of PD-1/PD-L1 interactions. Here we present results from patients with mCRC (n = 22) treated with the anti-PD-L1 monoclonal antibody avelumab. METHODS: Patients received treatment on a phase I, open-label, dose-escalation trial via a consecutive parallel-group expansion in colorectal cancer. Patients aged 18 years and older with mCRC measurable by RECIST v1.1 who had received at least 1 line of systemic therapy for metastatic disease enrolled. Patients with prior immune checkpoint inhibitor treatment were excluded. Patients received avelumab 10 mg/kg intravenously every 2 weeks. The primary endpoint was the objective response rate. RESULTS: Twenty-two participants received treatment from July 2013 to August 2014. There were no objective responses and median progression-free survival was 2.1 months (95% CI: 1.4-5.5 months). There were 5 grade 3 treatment-related adverse events: GGT elevation (n = 2), PRESS (n = 1), lymphopenia (n = 1), and asymptomatic amylase/lipase elevation (n = 1). CONCLUSION: As demonstrated with other anti-PD-1/PD-L1 monoclonal antibodies, avelumab is not active in unselected patients with mCRC (ClinicalTrials.gov Identifier: NCT01772004).","journal":"The Oncologist","year":2023,"id":365663,"datarank":0.33162515597057046,"base_score":1.9459101490553132,"endowment":1.9459101490553132,"self_citation_contribution":0.29188652235829704,"citation_network_contribution":0.03973863361227342,"self_endowment_contribution":0.29188652235829704,"citer_contribution":0.03973863361227342,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":6,"citers_with_citation_signal":5,"citers_with_endowment":5,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9479,"is_data_producer":true,"deposit_databanks":{"ClinicalTrials.gov":["NCT01772004"]},"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":279363,"name":"Geraldine O’Sullivan Coyne","orcid":"0000-0002-2918-6326","position":1,"is_corresponding":false},{"id":1121520,"name":"Clay T. Reed","orcid":"0000-0001-9671-5219","position":2,"is_corresponding":false},{"id":256072,"name":"Ravi A. Madan","orcid":"0000-0001-5106-8636","position":3,"is_corresponding":false},{"id":239941,"name":"Julius Strauss","orcid":"0000-0002-7550-4938","position":4,"is_corresponding":false},{"id":1121941,"name":"Seth J Steinberg","orcid":null,"position":5,"is_corresponding":false},{"id":257287,"name":"Jennifer L. Marté","orcid":null,"position":6,"is_corresponding":false},{"id":256067,"name":"Lisa M. Cordes","orcid":"0000-0003-3833-4084","position":7,"is_corresponding":false},{"id":303156,"name":"Christopher R. Heery","orcid":null,"position":8,"is_corresponding":false},{"id":239942,"name":"James L. Gulley","orcid":"0000-0002-6569-2912","position":9,"is_corresponding":false},{"id":256065,"name":"Jason M. Redman","orcid":"0000-0001-8200-0167","position":0,"is_corresponding":true}],"reference_count":35,"raw_metadata":null,"created_at":"2026-07-19T01:14:50.885797Z","pmid":"37310790","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}