{"doi":"10.1093/oncolo/oyac004","title":"Safety and Tolerability of Carboplatin and Paclitaxel in Cancer Patients with HIV (AMC-078), an AIDS Malignancy Consortium (AMC) Study","abstract":"BACKGROUND: Persons living with human immunodeficiency virus are an underserved population for evidence-based cancer treatment. Paclitaxel and carboplatin (PCb) is an active regimen against a variety of solid tumors, including several seen in excess in patients with HIV infection. We performed a pilot trial to evaluate the safety of full-dose PCb in people living with human immunodeficiency virus and cancer. METHODS: Eligible patients, stratified by concurrent antiretroviral therapy (ART) that included CYP3A4 inhibitors or not, received paclitaxel (175 mg/m2) in combination with carboplatin (target AUC 6) intravenously every 3 weeks for up to 6 cycles. RESULTS: Sixteen evaluable patients received 64 cycles of PCb, including 6 patients treated with CYP3A4 inhibiting ART (ritonavir). The adverse event profile was consistent with the known toxicity profile of PCb, with no differences between the 2 strata. There were 4 partial responses (25%, 95% CI: 7%-52%), and overall, CD4+ lymphocyte count was similar after completion of therapy (median: 310/μL) compared with baseline values (median: 389/μL). Pharmacokinetic studies in 6 patients revealed no significant differences in Cmax or AUCinf for paclitaxel between the 2 cohorts. CONCLUSION: Full doses of PCb chemotherapy are tolerable when given concurrently with ART in people living with human immunodeficiency virus with cancer, including patients receiving CYP3A4 inhibitors. CLINICALTRIALS.GOV IDENTIFIER: NCT01249443.","journal":"The Oncologist","year":2022,"id":284552,"datarank":0.31700824989667953,"base_score":1.791759469228055,"endowment":1.791759469228055,"self_citation_contribution":0.26876392038420827,"citation_network_contribution":0.04824432951247128,"self_endowment_contribution":0.26876392038420827,"citer_contribution":0.04824432951247128,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":5,"citers_with_citation_signal":5,"citers_with_endowment":5,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9462,"is_data_producer":true,"deposit_databanks":{"ClinicalTrials.gov":["NCT01249443"]},"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":308653,"name":"Page C. Moore","orcid":"0000-0002-3428-8781","position":1,"is_corresponding":false},{"id":30680,"name":"Milan Bimali","orcid":"0000-0002-4446-3977","position":2,"is_corresponding":false},{"id":962316,"name":"Timothy P. Cooley","orcid":"0000-0002-3373-1569","position":3,"is_corresponding":false},{"id":245492,"name":"Joseph A. Sparano","orcid":"0000-0002-9031-2010","position":4,"is_corresponding":false},{"id":430620,"name":"Michelle A. Rudek","orcid":"0000-0001-5739-6868","position":5,"is_corresponding":false},{"id":308657,"name":"Lee Ratner","orcid":"0000-0003-2744-7294","position":6,"is_corresponding":false},{"id":411776,"name":"David H. Henry","orcid":"0000-0002-9122-2623","position":7,"is_corresponding":false},{"id":411774,"name":"Juan Carlos Ramos","orcid":"0000-0002-3769-6035","position":8,"is_corresponding":false},{"id":482281,"name":"John F. Deeken","orcid":"0000-0001-8414-1553","position":9,"is_corresponding":false},{"id":308654,"name":"P Rubinstein","orcid":"0000-0002-0724-461X","position":10,"is_corresponding":false},{"id":292068,"name":"Elizabeth Y. Chiao","orcid":"0000-0001-5752-2916","position":11,"is_corresponding":false},{"id":962315,"name":"Missak Haigentz","orcid":"0000-0002-3610-2266","position":0,"is_corresponding":true}],"reference_count":31,"raw_metadata":null,"created_at":"2026-07-19T00:29:36.828109Z","pmid":"35429391","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}