{"doi":"10.1093/omcr/omaa006","title":"Remarkable response of a patient with secondary glioblastoma to a histone deacetylase inhibitor","abstract":"Secondary glioblastoma is a rare brain tumor characterized by a mutation in isocitrate dehydrogenase, which is reported to lead to epigenetic modification. Patients with secondary glioblastoma experience poor survival and quality-of-life outcomes due to the disease's aggressiveness and a lack of targeted therapies. In this report, a patient with a secondary glioblastoma was treated with a histone deacetylase inhibitor, an epigenetic drug with potent anti-inflammatory properties, in addition to the standard regimen. The patient showed very favorable survival and quality-of-life measures, and a restoration of several neuro-metabolites as measured by spectroscopic magnetic resonance imaging.","journal":"Oxford Medical Case Reports","year":2020,"id":83375,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":11,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9517,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":428905,"name":"Brent D. Weinberg","orcid":"0000-0002-7992-1747","position":1,"is_corresponding":false},{"id":429589,"name":"Eric Salgado","orcid":null,"position":2,"is_corresponding":false},{"id":429590,"name":"Alfredo Voloschin","orcid":null,"position":3,"is_corresponding":false},{"id":429591,"name":"Jose Enrique Velazquez Vega","orcid":null,"position":4,"is_corresponding":false},{"id":426290,"name":"Jeffrey J. Olson","orcid":"0000-0002-9968-681X","position":5,"is_corresponding":false},{"id":294153,"name":"Hui‐Kuo G. Shu","orcid":"0000-0002-4060-0874","position":6,"is_corresponding":false},{"id":375815,"name":"Hyunsuk Shim","orcid":"0000-0001-8313-2612","position":7,"is_corresponding":false},{"id":428904,"name":"Saumya Gurbani","orcid":"0000-0003-3524-3726","position":0,"is_corresponding":true}],"reference_count":11,"raw_metadata":null,"created_at":"2026-07-18T21:54:09.383533Z","pmid":"32257248","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}