{"doi":"10.1093/ofid/ofaf696","title":"Melanocortin-4 Receptor Gene Variants and Weight Change Following Switch to Integrase Inhibitor-Based Antiretroviral Therapy","abstract":"Abstract Given the melanocortin-4 receptor's (MC4R) importance in obesity, we examined associations between MC4R gene variants and weight following a switch to integrase inhibitor-containing antiretroviral therapy among participants in Advancing Clinical Therapeutics Globally studies. Among 529 persons with HIV (median age: 50 years, 29% non-Hispanic Black, 22% female), 62% were overweight or obese at integrase strand transfer inhibitor switch, and 62% switched to raltegravir. In adjusted linear models, three variants were associated (P < .05) with weight change after switch in all participants or in prespecified subgroups. These exploratory findings are consistent with the role of melanocortins in appetite and weight and suggest a neuroendocrine contribution to integrase inhibitor-related weight gain.","journal":"Open Forum Infectious Diseases","year":2025,"id":583635,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9471,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":242505,"name":"Kristine M. Erlandson","orcid":"0000-0003-0808-6729","position":1,"is_corresponding":false},{"id":98505,"name":"Yuki Bradford","orcid":null,"position":2,"is_corresponding":false},{"id":247285,"name":"Katherine Tassiopoulos","orcid":"0000-0003-4773-2535","position":3,"is_corresponding":false},{"id":248794,"name":"Kunling Wu","orcid":null,"position":4,"is_corresponding":false},{"id":247281,"name":"Sara H Bares","orcid":"0000-0002-2130-2505","position":5,"is_corresponding":false},{"id":109430,"name":"Todd T. Brown","orcid":"0000-0001-8599-278X","position":6,"is_corresponding":false},{"id":240258,"name":"Jordan E. Lake","orcid":"0000-0002-0640-5514","position":7,"is_corresponding":false},{"id":352295,"name":"Michael Leonard","orcid":null,"position":8,"is_corresponding":false},{"id":247284,"name":"Grace A. McComsey","orcid":"0000-0003-2690-8888","position":9,"is_corresponding":false},{"id":22049,"name":"Marylyn D. Ritchie","orcid":"0000-0002-1208-1720","position":10,"is_corresponding":false},{"id":331298,"name":"Paul E. Sax","orcid":"0000-0001-8434-174X","position":11,"is_corresponding":false},{"id":240259,"name":"John R. Koethe","orcid":"0000-0001-6490-6942","position":12,"is_corresponding":false},{"id":292655,"name":"David W. Haas","orcid":"0000-0002-5813-1594","position":13,"is_corresponding":false},{"id":351139,"name":"Todd Hulgan","orcid":"0000-0002-3339-067X","position":0,"is_corresponding":true}],"reference_count":52,"raw_metadata":null,"created_at":"2026-07-19T02:59:07.970345Z","pmid":"41322244","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}