{"doi":"10.1093/ofid/ofaf585","title":"Features of Carbapenem-resistant Gram-negative Bacterial Infections in Japan Based on the Setting of Onset","abstract":"Background: Carbapenem-resistant Gram-negative bacilli (CR-GNB) are a major public health threat, traditionally linked to hospital settings. However, infections are increasingly reported in the community, and the clinical distinctions between community-associated (CA) and healthcare-associated (HA) infections remain unclear. Methods: We conducted a prospective multicenter study of hospitalized patients with CR-GNB infections across 13 Japanese tertiary hospitals between April 2019 and March 2024. Infections were categorized as CA, HA, or hospital-onset (HO) using standardized criteria. We compared patient demographics, microbiological findings, infection sites, and clinical outcomes based on the setting of onset. Results: was detected almost exclusively among HO cases. Hospital-onset infections were associated with longer median hospital stays compared with CA infections (68 vs 17 days) and a trend toward higher 30-day mortality (23.9% vs 9.5%). In contrast, HA infections demonstrated no significant differences from CA infections in either hospital length of stay (23 vs 17 days) or 30-day mortality rate (10.3% vs 9.5%). Conclusions: Community-associated CR-GNB infections are an emerging concern in Japan, showing distinct pathogen profiles and infection sites compared to HO cases. Importantly, HA infections resembled CA infections in terms of clinical characteristics and outcomes, suggesting a need to reexamine the clinical relevance of current HA classification criteria for guiding therapy and risk stratification.","journal":"Open Forum Infectious Diseases","year":2025,"id":576076,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9434,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":652892,"name":"Yusuke Asai","orcid":"0000-0003-2979-3449","position":1,"is_corresponding":false},{"id":962231,"name":"Aki Sakurai","orcid":"0000-0003-2198-8954","position":2,"is_corresponding":false},{"id":1038849,"name":"Yasufumi Matsumura","orcid":"0000-0001-8595-8944","position":3,"is_corresponding":false},{"id":1256331,"name":"Ryota Hase","orcid":"0000-0002-3135-1757","position":4,"is_corresponding":false},{"id":641898,"name":"Hideaki Kato","orcid":"0000-0002-7853-5721","position":5,"is_corresponding":false},{"id":1400093,"name":"Takashi Matono","orcid":"0000-0001-9957-0510","position":6,"is_corresponding":false},{"id":1256332,"name":"Naoya Itoh","orcid":"0000-0001-6269-7884","position":7,"is_corresponding":false},{"id":77652,"name":"Takehiro Hashimoto","orcid":null,"position":8,"is_corresponding":false},{"id":1484669,"name":"Go Yamamoto","orcid":"0000-0001-9229-2976","position":9,"is_corresponding":false},{"id":1484670,"name":"Momoko Mawatari","orcid":"0000-0002-8953-5962","position":10,"is_corresponding":false},{"id":840231,"name":"Takeya Tsutsumi","orcid":"0000-0003-0851-1887","position":11,"is_corresponding":false},{"id":641900,"name":"Tetsuya Suzuki","orcid":"0000-0003-3165-9062","position":12,"is_corresponding":false},{"id":1484671,"name":"Shinya Tsuzuki","orcid":"0000-0002-8504-1244","position":13,"is_corresponding":false},{"id":1307994,"name":"Koji Ohyama","orcid":"0000-0002-8472-0413","position":14,"is_corresponding":false},{"id":704802,"name":"Masahiro Suzuki","orcid":"0000-0003-4550-3499","position":15,"is_corresponding":false},{"id":506151,"name":"Kayoko Hayakawa","orcid":"0000-0002-5480-4405","position":16,"is_corresponding":false},{"id":1256823,"name":"Kohei Uemura","orcid":null,"position":17,"is_corresponding":false},{"id":232741,"name":"David van Duin","orcid":"0000-0003-4784-3227","position":18,"is_corresponding":false},{"id":103444,"name":"Norio Ohmagari","orcid":"0000-0002-4622-8970","position":19,"is_corresponding":false},{"id":232746,"name":"Yohei Doi","orcid":"0000-0002-9620-2525","position":20,"is_corresponding":false},{"id":139730,"name":"Sho Saito","orcid":null,"position":21,"is_corresponding":false},{"id":1484991,"name":"Yuya Kawamoto","orcid":null,"position":0,"is_corresponding":true}],"reference_count":33,"raw_metadata":null,"created_at":"2026-07-19T02:57:56.636458Z","pmid":"41103782","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}