{"doi":"10.1093/ofid/ofaf285","title":"Early Virologic Success on Antiretroviral Therapy Among Individuals With Breakthrough HIV Acquisition on Long-Acting Cabotegravir Pre-exposure Prophylaxis","abstract":"HIV-1 breakthrough on long-acting cabotegravir (CAB-LA) for HIV prevention is rare but could impact viral suppression on integrase strand transfer inhibitor (INSTI)-based antiretroviral therapy (ART). We report the first study of ART outcomes following CAB-LA breakthrough during routine clinical care. Three individuals acquired HIV-1 on CAB-LA despite on-time injections; 2 had low-frequency major INSTI resistance mutations. All started darunavir-based ART; 1 subsequently switched to bictegravir-based ART. All maintained plasma HIV-1 RNA <50 copies/mL through ≥5 months post-ART initiation, providing early evidence of virologic success with standard ART regimens and paving the way for longer-term studies on optimal ART after CAB-LA breakthrough.","journal":"Open Forum Infectious Diseases","year":2025,"id":544161,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9559,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":639943,"name":"Monica Gandhi","orcid":"0000-0001-6674-5388","position":1,"is_corresponding":false},{"id":1434767,"name":"Jessica Altamirano","orcid":null,"position":2,"is_corresponding":false},{"id":1210899,"name":"Hussein Safa","orcid":"0000-0001-9611-6961","position":3,"is_corresponding":false},{"id":571637,"name":"Aniruddha Hazra","orcid":"0000-0001-8557-4465","position":4,"is_corresponding":false},{"id":1254008,"name":"Lisa Georgetti Gomez","orcid":null,"position":5,"is_corresponding":false},{"id":1434768,"name":"Prerak Shukla","orcid":null,"position":6,"is_corresponding":false},{"id":1434426,"name":"Trevor Hedberg","orcid":"0000-0002-4460-8275","position":7,"is_corresponding":false},{"id":629746,"name":"Amy Heaps","orcid":"0000-0003-4410-4007","position":8,"is_corresponding":false},{"id":258954,"name":"Elias K. Halvas","orcid":"0000-0002-4890-1209","position":9,"is_corresponding":false},{"id":452238,"name":"Karen Kuncze","orcid":null,"position":10,"is_corresponding":false},{"id":451361,"name":"Hideaki Okochi","orcid":"0000-0002-8519-7409","position":11,"is_corresponding":false},{"id":613244,"name":"Charles Walworth","orcid":null,"position":12,"is_corresponding":false},{"id":658822,"name":"Amy A. Conroy","orcid":"0000-0002-0609-5077","position":13,"is_corresponding":false},{"id":1434769,"name":"Chris Bositis","orcid":null,"position":14,"is_corresponding":false},{"id":1029514,"name":"Carolyn Chu","orcid":"0000-0003-0780-1081","position":15,"is_corresponding":false},{"id":258969,"name":"John W. Mellors","orcid":"0000-0002-3737-9742","position":16,"is_corresponding":false},{"id":255273,"name":"Catherine A. Koss","orcid":"0000-0002-7297-175X","position":17,"is_corresponding":false},{"id":629745,"name":"Urvi M. Parikh","orcid":"0000-0002-4016-0629","position":0,"is_corresponding":true}],"reference_count":14,"raw_metadata":null,"created_at":"2026-07-19T02:53:12.864581Z","pmid":"40476034","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}