{"doi":"10.1093/ofid/ofae346","title":"Oral Lipid Nanocrystal Amphotericin B (MAT2203) for the Treatment of Invasive Fungal Infections","abstract":"<jats:title>Abstract</jats:title>\n               <jats:p>Amphotericin B (AmB) has broad fungicidal activity against many fungi, but the high incidence of adverse events, particularly nephrotoxicity, and the need for intravenous administration restrict its use for many patients. MAT2203, an investigational oral AmB formulation available under a compassionate use program, uses a lipid nanocrystal bilayer structure to deliver AmB with lower toxicity. We present a synopsis of clinical characteristics, treatment course, and outcomes for 5 patients who were treated with MAT2203. Outcomes were positive, with cure of infection noted in 4 patients and improvement in 1 patient who remains on therapy. MAT2203 was well tolerated with only modest gastrointestinal adverse effects. This new oral formulation might provide a safer treatment option for patients requiring extended courses of AmB.</jats:p>","journal":"Open Forum Infectious Diseases","year":2024,"id":634174,"datarank":0.38474240361923057,"base_score":2.5649493574615367,"endowment":2.5649493574615367,"self_citation_contribution":0.38474240361923057,"citation_network_contribution":0.0,"self_endowment_contribution":0.38474240361923057,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":12,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1644631,"name":"Carol A Kauffman","orcid":null,"position":1,"is_corresponding":false},{"id":338717,"name":"Marisa H. Miceli","orcid":"0000-0002-3175-0512","position":2,"is_corresponding":false},{"id":1644630,"name":"Liam M Dalton","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Oral Lipid Nanocrystal Amphotericin B (MAT2203) for the Treatment of Invasive Fungal Infections","abstract":"<jats:title>Abstract</jats:title>\n               <jats:p>Amphotericin B (AmB) has broad fungicidal activity against many fungi, but the high incidence of adverse events, particularly nephrotoxicity, and the need for intravenous administration restrict its use for many patients. MAT2203, an investigational oral AmB formulation available under a compassionate use program, uses a lipid nanocrystal bilayer structure to deliver AmB with lower toxicity. We present a synopsis of clinical characteristics, treatment course, and outcomes for 5 patients who were treated with MAT2203. Outcomes were positive, with cure of infection noted in 4 patients and improvement in 1 patient who remains on therapy. MAT2203 was well tolerated with only modest gastrointestinal adverse effects. This new oral formulation might provide a safer treatment option for patients requiring extended courses of AmB.</jats:p>","is_dataset_classified":null,"base_score":2.5649493574615367,"endowment":2.5649493574615367,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"38989533","pmcid":"PMC11234142","openalex_id":"https://openalex.org/W4399952089","authors":[],"funders":[],"total_grants":0,"fwci":3.6244,"citation_percentile":0.93898831,"influential_citations":0,"citation_trend":[{"year":2025,"count":7},{"year":2026,"count":5}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://academic.oup.com/ofid/advance-article-pdf/doi/10.1093/ofid/ofae346/58319391/ofae346.pdf","host_type":"journal"},{"url":"https://academic.oup.com/ofid/advance-article-pdf/doi/10.1093/ofid/ofae346/58319391/ofae346.pdf","host_type":"publisher"},{"url":"https://academic.oup.com/ofid/article-pdf/11/7/ofae346/58650858/ofae346.pdf","host_type":"publisher"},{"url":"https://doi.org/10.1093/ofid/ofae346","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/38989533","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11234142","host_type":"repository"},{"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11234142/pdf/ofae346.pdf","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC11234142","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC11234142?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Antifungal resistance and susceptibility","Fungal Infections and Studies","Nail Diseases and Treatments"],"mesh_terms":[],"keywords":["Medicine","Amphotericin B","Pathogenic organism","Microbiology","Antifungal","Dermatology","Biology","Invasive Fungal Infections","Antifungal Treatment","Oral Amphotericin B","Antifungals Pipeline","Novel Antifungal Agents"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-06T13:16:46.490627Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}