{"doi":"10.1093/ofid/ofae265","title":"Patient Attitudes Toward Self- or Partner-, Friend-, or Family-Administered Long-acting Injectable Antiretroviral Therapy: A Mixed-Methods Study Across 3 Urban Human Immunodeficiency Virus Clinics","abstract":"Background: Long-acting injectable (LAI) cabotegravir/rilpivirine (CAB/RPV) offers a novel drug delivery option for persons with human immunodeficiency virus (PWH) but requires administration every 4 or 8 weeks by a medical professional. Methods: To facilitate LAI antiretroviral therapy (ART) scale-up, we evaluated patient interest in alternative administration approaches via a mixed-methods, serial cross-sectional study across 3 US HIV clinics. We surveyed PWH (December 2021 to May 2022) on appeal of self- or partner/friend/family-administered LAI-CAB/RPV; multivariable ordinal logistic regression explored associated characteristics. To contextualize survey results, we thematically analyzed semi-structured interview data collected from PWH (August 2020 to July 2021) on attitudes toward out-of-clinic LAI-ART administration. Results: Among 370 surveyed PWH (median age, 46 years; 26% cisgender female, 59% Black, 56% sexual minority, 34% housing instability), self-administering LAI-CAB/RPV appealed to 67%. PWH who were White (adjusted odds ratio [aOR], 3.30 [95% confidence interval {CI}, 1.42-7.64]), stably housed (aOR, 2.16 [95% CI, 1.30-3.59]), or gay/bisexual (aOR, 1.81 [1.14-2.89]) were more likely to endorse self-administration. Fewer PWH (60%) reported partner/friend/family administration as appealing; adjusted models revealed similar sociodemographic preferences for this outcome. In 72 interviews, PWH noted that acceptability of out-of-clinic LAI-ART administration was qualified by convenience, prior injection experience, and potential fear of self-inflicted pain, dependence on others, and/or HIV disclosure. Conclusions: In a multisite sample of PWH, self- and, to a lesser extent, partner/friend/family-administration of LAI-CAB/RPV appealed to most; however, was less appealing among populations more impacted by health disparities. Innovative LAI-ART delivery options could free up in-clinic resources to focus scale-up among marginalized populations.","journal":"Open Forum Infectious Diseases","year":2024,"id":436686,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":11,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9579,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":428434,"name":"Kimberly A. Koester","orcid":"0000-0003-0023-1127","position":1,"is_corresponding":false},{"id":383133,"name":"Moira McNulty","orcid":"0000-0002-9651-254X","position":2,"is_corresponding":false},{"id":1245501,"name":"Elizabeth T Montgomery","orcid":null,"position":3,"is_corresponding":false},{"id":313569,"name":"Mallory O. Johnson","orcid":"0000-0003-0480-2804","position":4,"is_corresponding":false},{"id":75618,"name":"Torsten B. Neilands","orcid":"0000-0001-7936-9123","position":5,"is_corresponding":false},{"id":428435,"name":"Samantha E. Dilworth","orcid":"0000-0002-5451-5486","position":6,"is_corresponding":false},{"id":404317,"name":"John A. Sauceda","orcid":"0000-0003-1975-3080","position":7,"is_corresponding":false},{"id":857957,"name":"Kaylin V. Dance","orcid":"0000-0001-6419-7162","position":8,"is_corresponding":false},{"id":721900,"name":"Xavier A. Erguera","orcid":"0000-0002-7632-0321","position":9,"is_corresponding":false},{"id":908567,"name":"Manami Diaz Tsuzuki","orcid":null,"position":10,"is_corresponding":false},{"id":557902,"name":"José I. Gutierrez","orcid":"0000-0003-3231-0794","position":11,"is_corresponding":false},{"id":1135478,"name":"Katerina A Christopoulos","orcid":null,"position":12,"is_corresponding":false},{"id":437628,"name":"Jonathan Colasanti","orcid":"0000-0002-0536-9769","position":13,"is_corresponding":false},{"id":301947,"name":"Lauren F. Collins","orcid":"0000-0002-0170-5454","position":0,"is_corresponding":true}],"reference_count":26,"raw_metadata":null,"created_at":"2026-07-19T02:00:16.989773Z","pmid":"38854389","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}