{"doi":"10.1093/ofid/ofae262","title":"Multisite Study of the Management of Musculoskeletal Infection After Trauma: The MMUSKIT Study","abstract":"Abstract Background The optimal duration and choice of antibiotic for fracture-related infection (FRI) is not well defined. This study aimed to determine whether antibiotic duration (≤6 vs >6 weeks) is associated with infection- and surgery-free survival. The secondary aim was to ascertain risk factors associated with surgery- and infection-free survival. Methods We performed a multicenter retrospective study of patients diagnosed with FRI between 2013 and 2022. The association between antibiotic duration and surgery- and infection-free survival was assessed by Cox proportional hazard models. Models were weighted by the inverse of the propensity score, calculated with a priori variables of hardware removal; infection due to Staphylococcus aureus, Staphylococcus lugdunensis, Pseudomonas or Candida species; and flap coverage. Multivariable Cox proportional hazard models were run with additional covariates including initial pathogen, need for flap, and hardware removal. Results Of 96 patients, 54 (56.3%) received ≤6 weeks of antibiotics and 42 (43.7%) received >6 weeks. There was no association between longer antibiotic duration and surgery-free survival (hazard ratio [HR], 0.95; 95% CI, .65–1.38; P = .78) or infection-free survival (HR, 0.77; 95% CI, .30–1.96; P = .58). Negative culture was associated with increased hazard of reoperation or death (HR, 3.52; 95% CI, 1.99–6.20; P < .001) and reinfection or death (HR, 3.71; 95% CI, 1.24–11.09; P < .001). Need for flap coverage had an increased hazard of reoperation or death (HR, 3.24; 95% CI, 1.61–6.54; P = .001). Conclusions The ideal duration of antibiotics to treat FRI is unclear. In this multicenter study, there was no association between antibiotic treatment duration and surgery- or infection-free survival.","journal":"Open Forum Infectious Diseases","year":2024,"id":467933,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8272,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":584640,"name":"Alaina S Ritter","orcid":"0000-0002-8216-3588","position":1,"is_corresponding":false},{"id":640719,"name":"Emily Poehlein","orcid":"0000-0003-1358-0086","position":2,"is_corresponding":false},{"id":302875,"name":"Cynthia L. Green","orcid":"0000-0002-0186-5191","position":3,"is_corresponding":false},{"id":1300505,"name":"Damon V. Briggs","orcid":"0009-0004-4145-6765","position":4,"is_corresponding":false},{"id":1300506,"name":"Tristan Chari","orcid":"0000-0003-1141-7293","position":5,"is_corresponding":false},{"id":455006,"name":"Aaron D Therien","orcid":"0000-0003-0674-3457","position":6,"is_corresponding":false},{"id":1300507,"name":"Alexandra H. Aitchison","orcid":"0000-0001-7470-0067","position":7,"is_corresponding":false},{"id":1300508,"name":"Kiera Lunn","orcid":"0000-0003-2537-1361","position":8,"is_corresponding":false},{"id":1300791,"name":"Christian F Zirbes","orcid":null,"position":9,"is_corresponding":false},{"id":1300792,"name":"Tanvi Manohar","orcid":null,"position":10,"is_corresponding":false},{"id":1300793,"name":"Diana V Rijo","orcid":null,"position":11,"is_corresponding":false},{"id":447549,"name":"Jennifer E. Hagen","orcid":"0000-0001-9023-262X","position":12,"is_corresponding":false},{"id":1300794,"name":"Michael T. Talerico","orcid":null,"position":13,"is_corresponding":false},{"id":957544,"name":"Malcolm R. DeBaun","orcid":"0000-0002-4391-5708","position":14,"is_corresponding":false},{"id":1300509,"name":"Christian A. Péan","orcid":"0000-0001-7445-1152","position":15,"is_corresponding":false},{"id":871168,"name":"Laura Certain","orcid":"0000-0002-2991-125X","position":16,"is_corresponding":false},{"id":755876,"name":"Sandra B. Nelson","orcid":"0000-0002-1949-7884","position":17,"is_corresponding":false},{"id":700266,"name":"Jessica Seidelman","orcid":"0000-0001-7117-513X","position":0,"is_corresponding":true}],"reference_count":18,"raw_metadata":null,"created_at":"2026-07-19T02:05:15.025255Z","pmid":"38854390","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}