{"doi":"10.1093/ofid/ofae060","title":"The Burden and Impact of Early Post-transplant Multidrug-Resistant Organism Detection Among Renal Transplant Recipients, 2005–2021","abstract":"Background: Reducing the burden of multidrug-resistant organism (MDRO) colonization and infection among renal transplant recipients (RTRs) may improve patient outcomes. We aimed to assess whether the detection of an MDRO or a comparable antibiotic-susceptible organism (CSO) during the early post-transplant (EPT) period was associated with graft loss and mortality among RTRs. Methods: We conducted a retrospective cohort study of RTRs transplanted between 2005 and 2021. EPT positivity was defined as a positive bacterial culture within 30 days of transplant. The incidence and prevalence of EPT MDRO detection were calculated. The primary outcome was a composite of 1-year allograft loss or mortality following transplant. Multivariable Cox hazard regression, competing risk, propensity score-weighted sensitivity, and subgroup analyses were performed. Results: Among 3507 RTRs, the prevalence of EPT MDRO detection was 1.3% (95% CI, 0.91%-1.69%) with an incidence rate per 1000 EPT-days at risk of 0.42 (95% CI, 0.31-0.57). Among RTRs who met survival analysis inclusion criteria (n = 3432), 91% (3138/3432) had no positive EPT cultures and were designated as negative controls, 8% (263/3432) had a CSO detected, and 1% (31/3432) had an MDRO detected in the EPT period. EPT MDRO detection was associated with the composite outcome (adjusted hazard ratio [aHR], 3.29; 95% CI, 1.21-8.92) and death-censored allograft loss (cause-specific aHR, 7.15; 95% CI, 0.92-55.5; subdistribution aHR, 7.15; 95% CI, 0.95-53.7). A similar trend was seen in the subgroup and sensitivity analyses. Conclusions: MDRO detection during the EPT period was associated with allograft loss, suggesting the need for increased strategies to optimize prevention of MDRO colonization and infection.","journal":"Open Forum Infectious Diseases","year":2024,"id":455359,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.964,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":408705,"name":"Geeta Karadkhele","orcid":"0000-0002-0267-9665","position":1,"is_corresponding":false},{"id":582374,"name":"Andrei Bombin","orcid":"0000-0003-2445-304X","position":2,"is_corresponding":false},{"id":1279557,"name":"Rockford Watkins","orcid":null,"position":3,"is_corresponding":false},{"id":485175,"name":"Chad Robichaux","orcid":"0009-0002-8403-5499","position":4,"is_corresponding":false},{"id":693672,"name":"Gillian Smith","orcid":"0000-0001-9288-7566","position":5,"is_corresponding":false},{"id":779354,"name":"Vivek B. Beechar","orcid":"0000-0003-1803-9520","position":6,"is_corresponding":false},{"id":915223,"name":"Danielle Barrios Steed","orcid":"0000-0002-3355-5577","position":7,"is_corresponding":false},{"id":232744,"name":"Jesse T. Jacob","orcid":"0000-0001-9811-6260","position":8,"is_corresponding":false},{"id":311517,"name":"Timothy D. Read","orcid":"0000-0001-8966-9680","position":9,"is_corresponding":false},{"id":517392,"name":"Sarah W. Satola","orcid":"0000-0002-3059-0342","position":10,"is_corresponding":false},{"id":504868,"name":"Christian P. Larsen","orcid":"0000-0001-6573-2649","position":11,"is_corresponding":false},{"id":109934,"name":"Colleen S. Kraft","orcid":"0000-0003-1757-8477","position":12,"is_corresponding":false},{"id":651863,"name":"Stephanie M. Pouch","orcid":"0000-0002-5628-2444","position":13,"is_corresponding":false},{"id":320945,"name":"Michael H. Woodworth","orcid":"0000-0002-6181-4599","position":14,"is_corresponding":false},{"id":237086,"name":"Ahmed Babiker","orcid":"0000-0003-0578-4871","position":0,"is_corresponding":true}],"reference_count":47,"raw_metadata":null,"created_at":"2026-07-19T02:03:17.458329Z","pmid":"38464488","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}