{"doi":"10.1093/ofid/ofad457","title":"Effectiveness of a Messenger RNA Vaccine Booster Dose Against Coronavirus Disease 2019 Among US Healthcare Personnel, October 2021–July 2022","abstract":"Background: Protection against symptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (coronavirus disease 2019 [COVID-19]) can limit transmission and the risk of post-COVID conditions, and is particularly important among healthcare personnel. However, lower vaccine effectiveness (VE) has been reported since predominance of the Omicron SARS-CoV-2 variant. Methods: We evaluated the VE of a monovalent messenger RNA (mRNA) booster dose against COVID-19 from October 2021 to June 2022 among US healthcare personnel. After matching case-participants with COVID-19 to control-participants by 2-week period and site, we used conditional logistic regression to estimate the VE of a booster dose compared with completing only 2 mRNA doses >150 days previously, adjusted for multiple covariates. Results: Among 3279 case-participants and 3998 control-participants who had completed 2 mRNA doses, we estimated that the VE of a booster dose against COVID-19 declined from 86% (95% confidence interval, 81%-90%) during Delta predominance to 65% (58%-70%) during Omicron predominance. During Omicron predominance, VE declined from 73% (95% confidence interval, 67%-79%) 14-60 days after the booster dose, to 32% (4%-52%) ≥120 days after a booster dose. We found that VE was similar by age group, presence of underlying health conditions, and pregnancy status on the test date, as well as among immunocompromised participants. Conclusions: A booster dose conferred substantial protection against COVID-19 among healthcare personnel. However, VE was lower during Omicron predominance, and waning effectiveness was observed 4 months after booster dose receipt during this period. Our findings support recommendations to stay up to date on recommended doses of COVID-19 vaccines for all those eligible.","journal":"Open Forum Infectious Diseases","year":2023,"id":361162,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":9,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9643,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":411327,"name":"Nicholas M. 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Schrading","orcid":"0000-0002-8303-7882","position":27,"is_corresponding":false},{"id":1072052,"name":"Brian Chinnock","orcid":"0000-0001-5456-6243","position":28,"is_corresponding":false},{"id":426849,"name":"David G. Beiser","orcid":"0000-0001-9676-087X","position":29,"is_corresponding":false},{"id":411338,"name":"Brett Faine","orcid":"0000-0002-5759-9857","position":30,"is_corresponding":false},{"id":411340,"name":"John P. Haran","orcid":"0000-0001-7311-1121","position":31,"is_corresponding":false},{"id":411345,"name":"Utsav Nandi","orcid":"0000-0003-3833-6194","position":32,"is_corresponding":false},{"id":1056178,"name":"Anne K. Chipman","orcid":"0000-0002-5688-9246","position":33,"is_corresponding":false},{"id":295506,"name":"Frank LoVecchio","orcid":"0000-0002-2920-9073","position":34,"is_corresponding":false},{"id":411335,"name":"David A. 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