{"doi":"10.1093/ofid/ofad410","title":"Successful Treatment of <i>Paecilomyces variotii</i> Pneumonia and Lupus Nephritis With Posaconazole-Cyclophosphamide Co-administration Without Drug Interaction–Induced Toxicity","abstract":"Abstract Paecilomyces variotii is an opportunistic mold that causes pulmonary infections in immunosuppressed humans that are often treated with triazole therapy. Lupus nephritis is a major cause of progressive kidney disease in patients with systemic lupus erythematosus, often requiring cyclophosphamide-based therapies. Triazole-cyclophosphamide co-administration is challenging as triazoles increase cyclophosphamide concentrations, which can worsen cyclophosphamide toxicity. We describe herein a patient with Paecilomyces variotii pneumonia and concomitant lupus nephritis who was successfully treated with posaconazole and echinocandin-bridged interruptions to allow for cyclophosphamide therapy. This regimen was well-tolerated without cyclophosphamide toxicity and achieved improvements in both fungal pneumonia and renal function.","journal":"Open Forum Infectious Diseases","year":2023,"id":378856,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9509,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1143373,"name":"Taura Webb","orcid":null,"position":1,"is_corresponding":false},{"id":285926,"name":"Elise M. N. Ferré","orcid":"0000-0002-3285-7768","position":2,"is_corresponding":false},{"id":390349,"name":"Monica M. Schmitt","orcid":"0000-0002-0726-5170","position":3,"is_corresponding":false},{"id":618909,"name":"Thomas DiMaggio","orcid":"0000-0002-3051-5553","position":4,"is_corresponding":false},{"id":296910,"name":"Dale Kobrin","orcid":null,"position":5,"is_corresponding":false},{"id":456676,"name":"Suraj Rajasimhan","orcid":"0000-0002-2920-5953","position":6,"is_corresponding":false},{"id":449608,"name":"Benjamin Colton","orcid":"0000-0002-8510-3628","position":7,"is_corresponding":false},{"id":254610,"name":"Russell E. Lewis","orcid":"0000-0002-2002-4339","position":8,"is_corresponding":false},{"id":251454,"name":"David R. Andes","orcid":"0000-0002-7927-9950","position":9,"is_corresponding":false},{"id":1143031,"name":"Alejandro Herrera","orcid":"0000-0003-4014-6808","position":10,"is_corresponding":false},{"id":110325,"name":"Dima A. Hammoud","orcid":"0000-0001-7406-7871","position":11,"is_corresponding":false},{"id":61356,"name":"Seyedmojtaba Seyedmousavi","orcid":"0000-0002-6194-7447","position":12,"is_corresponding":false},{"id":300740,"name":"Sarfaraz Hasni","orcid":"0000-0002-4164-8837","position":13,"is_corresponding":false},{"id":1143374,"name":"Jonathan Bolaños","orcid":null,"position":14,"is_corresponding":false},{"id":278231,"name":"Behdad Afzali","orcid":"0000-0003-2968-1156","position":15,"is_corresponding":false},{"id":104225,"name":"Michail S. Lionakis","orcid":"0000-0003-4994-9500","position":16,"is_corresponding":false},{"id":1132202,"name":"Joseph Pechacek","orcid":null,"position":0,"is_corresponding":true}],"reference_count":32,"raw_metadata":null,"created_at":"2026-07-19T01:16:48.594070Z","pmid":"37564740","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}