{"doi":"10.1093/ofid/ofad398","title":"Visceral Adiposity Index as a Measure of Cardiovascular Disease in Persons With Human Immunodeficiency Virus","abstract":"Abstract Background Persons with well-treated human immunodeficiency virus (HIV) demonstrate a 2-fold higher risk of cardiovascular disease (CVD), which may be related to excess visceral adipose tissue (VAT). The visceral adiposity index (VAI) is a score to approximate VAT by combining biochemical measures with anthropometrics without quantification by imaging. We evaluated VAI in association with cardiometabolic factors among persons with HIV (PWH). Methods Forty-five PWH on antiretroviral therapy and virologically controlled with increased abdominal VAT (VAT area >110 cm2 on CT) and no known CVD were included. VAI was calculated using standard sex-specific formulas. Coronary plaque was assessed using coronary CT angiography. Results Participants were predominantly male (73%), white (53%), and non-Hispanic (84%), with a mean age of 55 (standard deviation, 7) years. Among PWH, median VAI was calculated to be 4.9 (interquartile range [IQR], 2.8–7.3). Log VAI correlated with log VAT (r = 0.59, P < .0001) and anthropometric measures (body mass index: r = 0.36, P = .02; waist circumference: r = 0.43, P = .004; waist-to-hip ratio: r = 0.33, P = .03). Participants with coronary plaque had a higher VAI compared to those without coronary plaque (median, 5.3 [IQR, 3.4–10.5] vs 2.8 [IQR, 1.8–5.0]; P = .004). VAI (area under the curve = 0.760, P = .008) performed better than the atherosclerotic CVD risk score to predict the presence of plaque in receiver operating characteristic analyses. Conclusions VAI may be a useful biomarker of metabolic dysfunction and increased CVD risk that may occur with VAT accumulation in PWH. Clinical Trials Registration NCT02740179.","journal":"Open Forum Infectious Diseases","year":2023,"id":351456,"datarank":0.471592943203053,"base_score":2.302585092994046,"endowment":2.302585092994046,"self_citation_contribution":0.3453877639491069,"citation_network_contribution":0.12620517925394611,"self_endowment_contribution":0.3453877639491069,"citer_contribution":0.12620517925394611,"corpus_percentile":null,"corpus_rank":null,"citation_count":9,"citer_count":8,"citers_with_citation_signal":6,"citers_with_endowment":6,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9609,"is_data_producer":true,"deposit_databanks":{"ClinicalTrials.gov":["NCT02740179"]},"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1087069,"name":"Carolyn Dunderdale","orcid":null,"position":1,"is_corresponding":false},{"id":282485,"name":"Michael T. Lu","orcid":"0000-0003-4696-9610","position":2,"is_corresponding":false},{"id":802787,"name":"Allie R. Walpert","orcid":"0000-0002-0810-423X","position":3,"is_corresponding":false},{"id":802786,"name":"Grace Shen","orcid":"0000-0001-6023-8764","position":4,"is_corresponding":false},{"id":1096493,"name":"Michele C H Young","orcid":null,"position":5,"is_corresponding":false},{"id":270865,"name":"Martin Torriani","orcid":"0000-0002-6255-6413","position":6,"is_corresponding":false},{"id":338116,"name":"Jacqueline T. Chu","orcid":null,"position":7,"is_corresponding":false},{"id":1096494,"name":"Hanna H. Haptu","orcid":null,"position":8,"is_corresponding":false},{"id":1096495,"name":"Monica Manandhar","orcid":null,"position":9,"is_corresponding":false},{"id":311320,"name":"Alysse G. Wurcel","orcid":"0000-0002-8255-8387","position":10,"is_corresponding":false},{"id":419661,"name":"Gail K. Adler","orcid":"0000-0003-3506-7347","position":11,"is_corresponding":false},{"id":12007,"name":"Steven Grinspoon","orcid":"0000-0002-6338-000X","position":12,"is_corresponding":false},{"id":381597,"name":"Suman Srinivasa","orcid":"0000-0003-1950-4770","position":13,"is_corresponding":false},{"id":764525,"name":"Teressa S Thomas","orcid":"0000-0003-1803-8392","position":0,"is_corresponding":true}],"reference_count":31,"raw_metadata":null,"created_at":"2026-07-19T01:12:41.740237Z","pmid":"37559752","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}