{"doi":"10.1093/ofid/ofad271","title":"A Prospective Study of Key Correlates for Household Transmission of Severe Acute Respiratory Syndrome Coronavirus 2","abstract":"Background: Randomized controlled trials evaluated monoclonal antibodies for the treatment (Study 2067) and prevention (Study 2069) of coronavirus disease 2019 (COVID-19). Household contacts of the infected index case in Study 2067 were enrolled in Study 2069 and prospectively followed; these cohorts provided a unique opportunity to evaluate correlates of transmission, specifically viral load. Methods: This post hoc analysis was designed to identify and evaluate correlates of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission, adjusting for potential confounding factors related to source SARS-CoV-2 viral load and risk of SARS-CoV-2 acquisition in this population. Correlates of transmission were evaluated in potential transmission pairs (any infected household member plus susceptible household contact). Results: < .05) association with transmission risk. A 10-fold increase in viral load was associated with a 40% increase in odds of transmission; sharing a bedroom with the index participant was associated with a 199% increase in odds of transmission. Conclusions: In this prospective, post hoc analysis that controlled for confounders, the 2 key correlates for transmission of SARS-CoV-2 within a household are sharing a bedroom and increased viral load, consistent with increased exposure to the infected individual.","journal":"Open Forum Infectious Diseases","year":2023,"id":388279,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8377,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":596858,"name":"Meagan P. O’Brien","orcid":null,"position":1,"is_corresponding":false},{"id":871733,"name":"Brian Snow","orcid":null,"position":2,"is_corresponding":false},{"id":616051,"name":"Flonza Isa","orcid":"0000-0002-5422-8508","position":3,"is_corresponding":false},{"id":616050,"name":"Eduardo Forleo‐Neto","orcid":"0000-0003-1959-8156","position":4,"is_corresponding":false},{"id":617303,"name":"Kuo‐Chen Chan","orcid":null,"position":5,"is_corresponding":false},{"id":616052,"name":"Peijie Hou","orcid":"0000-0003-4899-7391","position":6,"is_corresponding":false},{"id":249712,"name":"Myron S. Cohen","orcid":"0000-0001-5917-9664","position":7,"is_corresponding":false},{"id":616057,"name":"Gary Herman","orcid":"0000-0003-4433-6529","position":8,"is_corresponding":false},{"id":315406,"name":"Ruanne V. Barnabas","orcid":"0000-0002-1793-6003","position":9,"is_corresponding":false},{"id":32390,"name":"Elizabeth R. Brown","orcid":"0000-0003-4286-2111","position":0,"is_corresponding":true}],"reference_count":24,"raw_metadata":null,"created_at":"2026-07-19T01:18:13.977537Z","pmid":"37416758","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}