{"doi":"10.1093/ofid/ofac078","title":"Candidemia Among Coronavirus Disease 2019 Patients in Turkey Admitted to Intensive Care Units: A Retrospective Multicenter Study","abstract":"Abstract Background We evaluated the epidemiology of candidemia among coronavirus disease 2019 (COVID-19) patients admitted to intensive care units (ICUs). Methods We conducted a retrospective multicenter study in Turkey between April and December 2020. Results Twenty-eight of 148 enrolled patients developed candidemia, yielding an incidence of 19% and incidence rate of 14/1000 patient-days. The probability of acquiring candidemia at 10, 20, and 30 days of ICU admission was 6%, 26%, and 50%, respectively. More than 80% of patients received antibiotics, corticosteroid, and mechanical ventilation. Receipt of a carbapenem (odds ratio [OR] = 6.0, 95% confidence interval [CI] = 1.6–22.3, P = .008), central venous catheter (OR = 4.3, 95% CI = 1.3–14.2, P = .02), and bacteremia preceding candidemia (OR = 6.6, 95% CI = 2.1–20.1, P = .001) were independent risk factors for candidemia. The mortality rate did not differ between patients with and without candidemia. Age (OR = 1.05, 95% CI = 1.01–1.09, P = .02) and mechanical ventilation (OR = 61, 95% CI = 15.8–234.9, P < .0001) were independent risk factors for death. Candida albicans was the most prevalent species overall. In Izmir, Candida parapsilosis accounted for 50% (2 of 4) of candidemia. Both C parapsilosis isolates were fluconazole nonsusceptible, harbored Erg11-Y132F mutation, and were clonal based on whole-genome sequencing. The 2 infected patients resided in ICUs with ongoing outbreaks due to fluconazole-resistant C parapsilosis. Conclusions Physicians should be aware of the elevated risk for candidemia among patients with COVID-19 who require ICU care. Prolonged ICU exposure and ICU practices rendered to COVID-19 patients are important contributing factors to candidemia. Emphasis should be placed on (1) heightened infection control in the ICU and (2) developing antibiotic stewardship strategies to reduce irrational antimicrobial therapy.","journal":"Open Forum Infectious Diseases","year":2022,"id":247369,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":33,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.6178,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":884920,"name":"Nevzat Ünal","orcid":"0000-0001-5121-3100","position":1,"is_corresponding":false},{"id":462393,"name":"Tuğrul Hoşbul","orcid":null,"position":2,"is_corresponding":false},{"id":884921,"name":"Muhammed Alper Özarslan","orcid":"0000-0003-0470-5959","position":3,"is_corresponding":false},{"id":884922,"name":"Ayşe Sultan Karakoyun","orcid":"0000-0002-2717-6343","position":4,"is_corresponding":false},{"id":884923,"name":"Furkan Polat","orcid":"0000-0003-4640-3991","position":5,"is_corresponding":false},{"id":884924,"name":"Diego Fuentes","orcid":"0000-0002-9977-6786","position":6,"is_corresponding":false},{"id":884925,"name":"Ramazan Gümral","orcid":"0000-0002-2303-8234","position":7,"is_corresponding":false},{"id":884926,"name":"Tuba Turunç","orcid":"0000-0002-0722-6964","position":8,"is_corresponding":false},{"id":260363,"name":"Farnaz Daneshnia","orcid":"0000-0002-8782-2036","position":9,"is_corresponding":false},{"id":235823,"name":"David S. Perlin","orcid":"0000-0002-9503-3184","position":10,"is_corresponding":false},{"id":235822,"name":"Cornelia Lass‐Flörl","orcid":"0000-0002-2946-7785","position":11,"is_corresponding":false},{"id":30341,"name":"Toni Gabaldón","orcid":"0000-0003-0019-1735","position":12,"is_corresponding":false},{"id":235821,"name":"Macit İlkit","orcid":"0000-0002-1174-4182","position":13,"is_corresponding":false},{"id":313420,"name":"M. Hong Nguyen","orcid":"0000-0003-2065-3239","position":14,"is_corresponding":false},{"id":235816,"name":"Amir Arastehfar","orcid":"0000-0002-4361-4841","position":0,"is_corresponding":true}],"reference_count":46,"raw_metadata":null,"created_at":"2026-07-19T00:23:53.369530Z","pmid":"35345665","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}