{"doi":"10.1093/ofid/ofab483","title":"Harnessing the Potential of Multiomics Studies for Precision Medicine in Infectious Disease","abstract":"The field of infectious diseases currently takes a reactive approach and treats infections as they present in patients. Although certain populations are known to be at greater risk of developing infection (eg, immunocompromised), we lack a systems approach to define the true risk of future infection for a patient. Guided by impressive gains in \"omics\" technologies, future strategies to infectious diseases should take a precision approach to infection through identification of patients at intermediate and high-risk of infection and deploy targeted preventative measures (ie, prophylaxis). The advances of high-throughput immune profiling by multiomics approaches (ie, transcriptomics, epigenomics, metabolomics, proteomics) hold the promise to identify patients at increased risk of infection and enable risk-stratifying approaches to be applied in the clinic. Integration of patient-specific data using machine learning improves the effectiveness of prediction, providing the necessary technologies needed to propel the field of infectious diseases medicine into the era of personalized medicine.","journal":"Open Forum Infectious Diseases","year":2021,"id":159705,"datarank":0.5570358100056463,"base_score":3.713572066704308,"endowment":3.713572066704308,"self_citation_contribution":0.5570358100056463,"citation_network_contribution":0.0,"self_endowment_contribution":0.5570358100056463,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":40,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9575,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":226949,"name":"Nima Aghaeepour","orcid":"0000-0002-6117-8764","position":1,"is_corresponding":false},{"id":35850,"name":"Roby P. Bhattacharyya","orcid":"0000-0001-6955-5088","position":2,"is_corresponding":false},{"id":6946,"name":"Clary B. Clish","orcid":"0000-0001-8259-9245","position":3,"is_corresponding":false},{"id":86469,"name":"Brice Gaudillière","orcid":"0000-0002-3475-5706","position":4,"is_corresponding":false},{"id":409,"name":"Nir Hacohen","orcid":"0000-0002-2349-2656","position":5,"is_corresponding":false},{"id":89098,"name":"Michael K. Mansour","orcid":"0000-0001-8892-8695","position":6,"is_corresponding":false},{"id":233402,"name":"Philip A. Mudd","orcid":"0000-0002-3860-5473","position":7,"is_corresponding":false},{"id":494255,"name":"Shravani Pasupneti","orcid":"0000-0002-7112-601X","position":8,"is_corresponding":false},{"id":552303,"name":"Rachel M. Presti","orcid":"0000-0002-5469-0727","position":9,"is_corresponding":false},{"id":268754,"name":"Eugene P. Rhee","orcid":"0000-0002-4804-7583","position":10,"is_corresponding":false},{"id":89067,"name":"Pritha Sen","orcid":"0000-0002-9102-4045","position":11,"is_corresponding":false},{"id":246252,"name":"Andrej Spec","orcid":"0000-0001-7612-4710","position":12,"is_corresponding":false},{"id":446732,"name":"Jenny M. Tam","orcid":"0000-0002-3767-7205","position":13,"is_corresponding":false},{"id":14837,"name":"Alexandra–Chloé Villani","orcid":"0000-0001-7461-0408","position":14,"is_corresponding":false},{"id":16976,"name":"Ann E. Woolley","orcid":"0000-0002-2810-1618","position":15,"is_corresponding":false},{"id":392502,"name":"Joe L. Hsu","orcid":"0000-0002-7050-6504","position":16,"is_corresponding":false},{"id":284649,"name":"Jatin M. Vyas","orcid":"0000-0002-9985-9565","position":17,"is_corresponding":false},{"id":270136,"name":"Rebecca Ward","orcid":"0000-0001-6752-5600","position":0,"is_corresponding":true}],"reference_count":117,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T23:44:39.550981Z","pmid":"34805429","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}