{"doi":"10.1093/ofid/ofab463","title":"Low-Level Viremia Is Associated With Cumulative Adherence to Antiretroviral Therapy in Persons With HIV","abstract":"The drivers of low-level viremia (LLV) between 20 and 200 copies/mL remain unclear. In 1042 person-visits from 497 persons with HIV on tenofovir disoproxil fumarate-containing antiretroviral therapy (ART), the association between LLV and cumulative antiretroviral adherence (quantified using tenofovir diphosphate [TFV-DP] in dried blood spots) was assessed. Lower TFV-DP levels were associated with higher odds of LLV. As TFV-DP (fmol/punch) categories decreased from >1650 to 800-1650; 800-1650 to <800; and >1650 to <800, the adjusted odds ratios for LLV vs HIV VL <20 copies/mL were 2.0 (95% CI, 1.2-3.1), 2.4 (95% CI, 1.1-5.0), and 4.6 (95% CI, 2.2-9.9), respectively. This suggests that adherence could impact LLV.","journal":"Open Forum Infectious Diseases","year":2021,"id":170323,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":28,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9611,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":395981,"name":"Mary Morrow","orcid":"0000-0002-2115-4864","position":1,"is_corresponding":false},{"id":395980,"name":"Ryan P Coyle","orcid":"0000-0001-6472-7020","position":2,"is_corresponding":false},{"id":396716,"name":"Stacey S. Coleman","orcid":null,"position":3,"is_corresponding":false},{"id":395983,"name":"Jia‐Hua Zheng","orcid":"0000-0003-1737-524X","position":4,"is_corresponding":false},{"id":396717,"name":"Lucas Ellison","orcid":null,"position":5,"is_corresponding":false},{"id":280276,"name":"Lane R. Bushman","orcid":null,"position":6,"is_corresponding":false},{"id":355013,"name":"Jennifer J. Kiser","orcid":null,"position":7,"is_corresponding":false},{"id":279022,"name":"Peter L. Anderson","orcid":"0000-0002-1200-8494","position":8,"is_corresponding":false},{"id":395984,"name":"Samantha MaWhinney","orcid":"0000-0002-9818-0059","position":9,"is_corresponding":false},{"id":395985,"name":"José Castillo‐Mancilla","orcid":"0000-0003-1242-1745","position":0,"is_corresponding":true}],"reference_count":25,"raw_metadata":null,"created_at":"2026-07-18T23:46:19.728805Z","pmid":"34584902","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}