{"doi":"10.1093/ofid/ofab203","title":"Soluble CD163 Identifies Those at Risk for Increased Hepatic Inflammation &amp; Fibrosis","abstract":"BACKGROUND: Liver disease remains a significant cause of morbidity and mortality in HIV-infected persons. Soluble CD163 is a marker of Kupffer cell activation that is highly associated with development of hepatic fibrosis. The relative contributions of HIV-associated systemic immune activation vs other etiologies of injury are poorly characterized. METHODS: We utilized subjects in the Miami Adult Studies on HIV (MASH) cohort to evaluate 464 participants including 361 people with HIV (PWH) and 103 hepatitis C virus (HCV)/HIV-uninfected controls. Subjects underwent testing for hepatic fibrosis using both magnetic resonance elastography and the Enhanced Liver Fibrosis Index. Steatosis was evaluated by magnetic resonance imaging-derived proton density fat fraction. Immune activation markers and cytokines were quantitated using Luminex methodologies. RESULTS: < .05). Soluble sCD163 was highly associated with elevated alanine aminotransferase, a key marker of inflammation/injury and with hepatic fibrosis. Hepatic steatosis was also associated with a cytokine pattern suggestive of Kupffer cell activation but was not associated with an increase in sCD14 or sCD27. CONCLUSIONS: Injury and resultant hepatic fibrosis occur by distinct though overlapping mechanistic pathways. In PWH, sCD163 is highly associated with both injury and fibrosis, suggesting that persistent systemic immune activation is a major contributor to long-term outcomes, adding to damage caused by alcohol, steatosis, and other hepatotoxic drug effects.","journal":"Open Forum Infectious Diseases","year":2021,"id":179385,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":18,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9555,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":726834,"name":"Heidi L. Meeds","orcid":"0009-0001-3123-135X","position":1,"is_corresponding":false},{"id":400237,"name":"Susan D. Rouster","orcid":"0000-0002-6457-4949","position":2,"is_corresponding":false},{"id":400236,"name":"Enass A. Abdel-hameed","orcid":"0000-0002-6921-9081","position":3,"is_corresponding":false},{"id":726835,"name":"Jacqueline Hernández","orcid":"0000-0002-6741-8124","position":4,"is_corresponding":false},{"id":379331,"name":"Javier Tamargo","orcid":"0000-0001-9385-9049","position":5,"is_corresponding":false},{"id":252214,"name":"Jun Chen","orcid":"0000-0002-1273-5624","position":6,"is_corresponding":false},{"id":275036,"name":"Richard L. Ehman","orcid":"0000-0001-7041-5074","position":7,"is_corresponding":false},{"id":516184,"name":"Marianna K. Baum","orcid":"0000-0002-6577-685X","position":8,"is_corresponding":false},{"id":307943,"name":"Kenneth E. Sherman","orcid":"0000-0002-0560-0019","position":0,"is_corresponding":true}],"reference_count":20,"raw_metadata":null,"created_at":"2026-07-18T23:47:48.974996Z","pmid":"34104667","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}