{"doi":"10.1093/ofid/ofaa600","title":"Myocardial Fibrosis Among Antiretroviral Therapy-Treated Persons With Human Immunodeficiency Virus in South Africa","abstract":"BACKGROUND: Heart failure is a prominent cardiovascular disease (CVD) manifestation in sub-Sarahan Africa. Myocardial fibrosis is a central feature of heart failure that we aimed to characterize among persons with human immunodeficiency virus (PWH) in South Africa. METHODS: Cardiovascular magnetic resonance (CMR) imaging was performed among PWH with viral suppression and uninfected controls, both free of known CVD. Plasma levels of N-terminal pro B-type natriuretic peptide (NT-proBNP) were measured. Comparisons by human immunodeficiency virus (HIV) status were made using linear and logistic regression, adjusted for age, sex, and hypertension. RESULTS: One hundred thirty-four PWH and 95 uninfected persons completed CMR imaging; age was 50 and 49 years, with 63% and 67% female, respectively. Compared with controls, PWH had greater myocardial fibrosis by extracellular volume fraction ([ECV] absolute difference, 1.2%; 95% confidence interval [CI], 0.1-2.3). In subgroup analyses, the effect of HIV status on ECV was more prominent among women. Women (vs controls) were also more likely to have elevated NT-proBNP levels (>125 pg/mL; odds ratio, 2.4; 95% CI, 1.0-6.0). Among all PWH, an elevated NT-proBNP level was associated with higher ECV (3.4% higher; 95% CI, 1.3-5.5). CONCLUSIONS: Human immunodeficiency virus disease may contribute to myocardial fibrosis, with an effect more prominent among women. Research is needed to understand heart failure risk among PWH within sub-Saharan Africa.","journal":"Open Forum Infectious Diseases","year":2020,"id":102814,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":26,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.7515,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":502236,"name":"Lye-Yeng Wong","orcid":null,"position":1,"is_corresponding":false},{"id":501457,"name":"Tess E. Peterson","orcid":"0000-0002-7223-651X","position":2,"is_corresponding":false},{"id":378086,"name":"Julian Wolfson","orcid":"0000-0002-2032-0875","position":3,"is_corresponding":false},{"id":501458,"name":"Stephen Jermy","orcid":"0000-0001-7045-3863","position":4,"is_corresponding":false},{"id":502237,"name":"H Huyer Abu Saad","orcid":null,"position":5,"is_corresponding":false},{"id":502238,"name":"Mbalabu A.J. Lumbamba","orcid":null,"position":6,"is_corresponding":false},{"id":501459,"name":"Avani Singh","orcid":"0000-0001-7494-2090","position":7,"is_corresponding":false},{"id":371678,"name":"Muki Shey","orcid":"0000-0002-8776-4737","position":8,"is_corresponding":false},{"id":292884,"name":"Graeme Meintjes","orcid":"0000-0003-1196-4414","position":9,"is_corresponding":false},{"id":91456,"name":"Ntobeko A. B. Ntusi","orcid":"0000-0003-2347-7883","position":10,"is_corresponding":false},{"id":103413,"name":"Mpiko Ntsekhe","orcid":"0000-0002-0851-7675","position":11,"is_corresponding":false},{"id":501460,"name":"Jason V. Baker","orcid":"0000-0002-5542-1545","position":12,"is_corresponding":false},{"id":502235,"name":"Scott R. Shuldiner","orcid":null,"position":0,"is_corresponding":true}],"reference_count":46,"raw_metadata":null,"created_at":"2026-07-18T22:41:53.173268Z","pmid":"33511232","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}