{"doi":"10.1093/ofid/ofaa446","title":"Treating COVID-19 With Hydroxychloroquine (TEACH): A Multicenter, Double-Blind Randomized Controlled Trial in Hospitalized Patients","abstract":"Abstract Background Effective therapies to combat coronavirus 2019 (COVID-19) are urgently needed. Hydroxychloroquine (HCQ) has in vitro antiviral activity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), but the clinical benefit of HCQ in treating COVID-19 is unclear. Randomized controlled trials are needed to determine the safety and efficacy of HCQ for the treatment of hospitalized patients with COVID-19. Methods We conducted a multicenter, double-blind randomized clinical trial of HCQ among patients hospitalized with laboratory-confirmed COVID-19. Subjects were randomized in a 1:1 ratio to HCQ or placebo for 5 days and followed for 30 days. The primary efficacy outcome was a severe disease progression composite end point (death, intensive care unit admission, mechanical ventilation, extracorporeal membrane oxygenation, and/or vasopressor use) at day 14. Results A total of 128 patients were included in the intention-to-treat analysis. Baseline demographic, clinical, and laboratory characteristics were similar between the HCQ (n = 67) and placebo (n = 61) arms. At day 14, 11 (16.4%) subjects assigned to HCQ and 6 (9.8%) subjects assigned to placebo met the severe disease progression end point, but this did not achieve statistical significance (P = .350). There were no significant differences in COVID-19 clinical scores, number of oxygen-free days, SARS-CoV-2 clearance, or adverse events between HCQ and placebo. HCQ was associated with a slight increase in mean corrected QT interval, an increased D-dimer, and a trend toward an increased length of stay. Conclusions In hospitalized patients with COVID-19, our data suggest that HCQ does not prevent severe outcomes or improve clinical scores. However, our conclusions are limited by a relatively small sample size, and larger randomized controlled trials or pooled analyses are needed.","journal":"Open Forum Infectious Diseases","year":2020,"id":59103,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":69,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9523,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":3907,"name":"Andrea B. Troxel","orcid":"0000-0002-1393-3075","position":1,"is_corresponding":false},{"id":310853,"name":"Ellie Carmody","orcid":"0000-0001-5297-4948","position":2,"is_corresponding":false},{"id":312849,"name":"Jaishvi Eapen","orcid":null,"position":3,"is_corresponding":false},{"id":310854,"name":"Martín Bäcker","orcid":"0000-0001-8061-5838","position":4,"is_corresponding":false},{"id":310855,"name":"Jack DeHovitz","orcid":"0000-0001-7307-0614","position":5,"is_corresponding":false},{"id":310856,"name":"Prithiv J. Prasad","orcid":"0000-0003-4142-067X","position":6,"is_corresponding":false},{"id":263826,"name":"Yi Li","orcid":"0000-0002-3875-3513","position":7,"is_corresponding":false},{"id":312850,"name":"Camila Delgado","orcid":null,"position":8,"is_corresponding":false},{"id":312851,"name":"Morris Jrada","orcid":null,"position":9,"is_corresponding":false},{"id":247444,"name":"Gabriel Robbins","orcid":"0000-0002-4447-0667","position":10,"is_corresponding":false},{"id":312852,"name":"Brooklyn Henderson","orcid":null,"position":11,"is_corresponding":false},{"id":310857,"name":"Alexander Hrycko","orcid":"0000-0001-8574-4639","position":12,"is_corresponding":false},{"id":312853,"name":"Dinuli Delpachitra","orcid":null,"position":13,"is_corresponding":false},{"id":38207,"name":"Vanessa Raabe","orcid":"0000-0003-2579-1104","position":14,"is_corresponding":false},{"id":304309,"name":"Jonathan Austrian","orcid":"0000-0002-0016-4705","position":15,"is_corresponding":false},{"id":310858,"name":"Yanina Dubrovskaya","orcid":"0000-0002-0369-7072","position":16,"is_corresponding":false},{"id":3883,"name":"Mark J. Mulligan","orcid":"0000-0001-7262-9746","position":17,"is_corresponding":false},{"id":3910,"name":"Robert J. Ulrich","orcid":"0000-0002-3217-5062","position":0,"is_corresponding":true}],"reference_count":37,"raw_metadata":null,"created_at":"2026-07-18T21:07:59.189921Z","pmid":"33134417","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}