{"doi":"10.1093/nutrit/nuab102","title":"Moderate alcohol consumption and lipoprotein subfractions: a systematic review of intervention and observational studies","abstract":"CONTEXT: Moderate alcohol consumption is associated with decreased risk of cardiovascular disease (CVD) and improvement in cardiovascular risk markers, including lipoproteins and lipoprotein subfractions. OBJECTIVE: To systematically review the relationship between moderate alcohol intake, lipoprotein subfractions, and related mechanisms. DATA SOURCES: Following PRISMA, all human and ex vivo studies with an alcohol intake up to 60 g/d were included from 8 databases. DATA EXTRACTION: A total of 17 478 studies were screened, and data were extracted from 37 intervention and 77 observational studies. RESULTS: Alcohol intake was positively associated with all HDL subfractions. A few studies found lower levels of small LDLs, increased average LDL particle size, and nonlinear relationships to apolipoprotein B-containing lipoproteins. Cholesterol efflux capacity and paraoxonase activity were consistently increased. Several studies had unclear or high risk of bias, and heterogeneous laboratory methods restricted comparability between studies. CONCLUSIONS: Up to 60 g/d alcohol can cause changes in lipoprotein subfractions and related mechanisms that could influence cardiovascular health. SYSTEMATIC REVIEW REGISTRATION: PROSPERO registration no. 98955.","journal":"Nutrition Reviews","year":2021,"id":188101,"datarank":0.6230914637567141,"base_score":2.8903717578961645,"endowment":2.8903717578961645,"self_citation_contribution":0.4335557636844247,"citation_network_contribution":0.18953570007228937,"self_endowment_contribution":0.4335557636844247,"citer_contribution":0.18953570007228937,"corpus_percentile":68.30664500657538,"corpus_rank":4098,"citation_count":17,"citer_count":14,"citers_with_citation_signal":11,"citers_with_endowment":11,"datacite_reuse_total":0,"is_dataset":true,"is_dataset_confidence":0.7772,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":748437,"name":"Kaare Tranæs","orcid":"0000-0002-2107-8523","position":1,"is_corresponding":false},{"id":393217,"name":"J. Eriksen","orcid":"0000-0002-3016-7480","position":2,"is_corresponding":false},{"id":393216,"name":"Lars Ove Dragsted","orcid":"0000-0003-0609-6317","position":3,"is_corresponding":false},{"id":393214,"name":"Trine Levring Wilkens","orcid":"0000-0001-9347-7120","position":0,"is_corresponding":true}],"reference_count":247,"raw_metadata":null,"created_at":"2026-07-18T23:49:05.976005Z","pmid":"34957513","pmcid":"PMC9308455","fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}