{"doi":"10.1093/nsr/nwac125","title":"Stability and dynamics of dendritic spines in macaque prefrontal cortex","abstract":"<jats:title>Abstract</jats:title>\n               <jats:p>Formation and elimination of synapses reflect structural plasticity of neuronal connectivity. Here we performed high-resolution two-photon imaging of dendritic spines in the prefrontal cortex of four macaque monkeys and found that spines were in general highly stable, with low percentages undergoing synaptic turnover. By observing the same spines at weekly intervals, we found that newly formed spines were more susceptible to elimination, with only 40% persisting over a period of months. Analyses of spatial distribution of large numbers of spines revealed that spine distribution was neither uniform nor random, favoring inter-spine distances of 2–4 μm. Furthermore, spine formation and elimination occurred more often in low- and high-density dendritic segments, respectively, and preferentially within a hot zone of ∼4 μm from existing spines. Our results demonstrate long-term stability and spatially regulated spine dynamics in the macaque cortex and provide a structural basis for understanding neural circuit plasticity in the primate brain.</jats:p>","journal":"National Science Review","year":2022,"id":649827,"datarank":0.4493598410330987,"base_score":2.995732273553991,"endowment":2.995732273553991,"self_citation_contribution":0.4493598410330987,"citation_network_contribution":0.0,"self_endowment_contribution":0.4493598410330987,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":19,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1694166,"name":"Junqian Qi","orcid":"0000-0001-9327-0381","position":1,"is_corresponding":false},{"id":1694168,"name":"Muming Poo","orcid":null,"position":2,"is_corresponding":false},{"id":588297,"name":"Yang Yang","orcid":"0000-0001-8572-5155","position":3,"is_corresponding":false},{"id":588975,"name":"Ming Chen","orcid":"0000-0003-2570-0858","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Stability and dynamics of dendritic spines in macaque prefrontal cortex","abstract":"<jats:title>Abstract</jats:title>\n               <jats:p>Formation and elimination of synapses reflect structural plasticity of neuronal connectivity. Here we performed high-resolution two-photon imaging of dendritic spines in the prefrontal cortex of four macaque monkeys and found that spines were in general highly stable, with low percentages undergoing synaptic turnover. By observing the same spines at weekly intervals, we found that newly formed spines were more susceptible to elimination, with only 40% persisting over a period of months. Analyses of spatial distribution of large numbers of spines revealed that spine distribution was neither uniform nor random, favoring inter-spine distances of 2–4 μm. Furthermore, spine formation and elimination occurred more often in low- and high-density dendritic segments, respectively, and preferentially within a hot zone of ∼4 μm from existing spines. Our results demonstrate long-term stability and spatially regulated spine dynamics in the macaque cortex and provide a structural basis for understanding neural circuit plasticity in the primate brain.</jats:p>","is_dataset_classified":null,"base_score":2.9444389791664403,"endowment":2.9444389791664403,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"36196248","pmcid":"PMC9521340","openalex_id":"https://openalex.org/W4283573876","authors":[],"funders":[{"funder_name":"National Natural Science Foundation of China","grant_id":"31970960","title":null}],"total_grants":1,"fwci":1.2879,"citation_percentile":0.77120303,"influential_citations":0,"citation_trend":[{"year":2023,"count":5},{"year":2024,"count":5},{"year":2025,"count":4},{"year":2026,"count":4}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://academic.oup.com/nsr/article-pdf/9/9/nwac125/46198498/nwac125.pdf","host_type":"journal"},{"url":"https://academic.oup.com/nsr/article-pdf/9/9/nwac125/46198498/nwac125.pdf","host_type":"publisher"},{"url":"https://academic.oup.com/nsr/advance-article-pdf/doi/10.1093/nsr/nwac125/44265417/nwac125.pdf","host_type":"publisher"},{"url":"https://doi.org/10.1093/nsr/nwac125","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/36196248","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9521340","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC9521340","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC9521340?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Neuroscience and Neuropharmacology Research","Neural dynamics and brain function","Functional Brain Connectivity Studies"],"mesh_terms":[],"keywords":["Dendritic spine","Macaque","SPINE (molecular biology)","Neuroscience","Biology","Prefrontal cortex","Dendritic filopodia","Cortex (anatomy)","Anatomy","Cell biology","Macaque monkey","Spine Plasticity","Dorsal Lateral Prefrontal Cortex","Dendritic Spine Distribution","Long-Term Two-Photon Imaging","Regulation Of Spine Dynamics"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-10T04:22:51.806799Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}