{"doi":"10.1093/nop/npac024","title":"Treatment of gliomas with temozolomide: Rather at sunrise or sunset?","abstract":null,"journal":"Neuro-Oncology Practice","year":2022,"id":633638,"datarank":0.10397207708399181,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"self_citation_contribution":0.10397207708399181,"citation_network_contribution":0.0,"self_endowment_contribution":0.10397207708399181,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":850558,"name":"Patrick Roth","orcid":"0000-0003-3897-214X","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Treatment of gliomas with temozolomide: Rather at sunrise or sunset?","abstract":"Treatment adapted to a specific time of the day is called chronotherapy or chronomedicine. In oncology, this approach has been considered of interest because the anti-cancer activity of some drugs may depend on circadian rhythms that exist in many organisms and may also be functionally relevant in tumor cells. Therefore, understanding the chronobiology of tumor cells has been an area of research over the last decades and a significant number of genes that are involved in the circadian biological rhythm have been identified and categorized as “clock genes”.1 While many aspects of chronobiology have only been partially understood, it seems clear that clock systems allow cells to react to changes in the (micro)environment in order to optimize their biological function. A quite large body of evidence suggests that the circadian clock in tumor cells is linked to DNA damage response mechanisms, which involve DNA damage checkpoints, nucleotide excision repair...","is_dataset_classified":null,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"35601973","pmcid":"PMC9113313","openalex_id":"https://openalex.org/W4221075538","authors":[],"funders":[],"total_grants":0,"fwci":0.0,"citation_percentile":0.02285952,"influential_citations":0,"citation_trend":[{"year":2026,"count":1}],"oa_status":"green","license":null,"oa_locations":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9113313","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9113313","host_type":"repository"},{"url":"https://doi.org/10.1093/nop/npac024","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/35601973","host_type":"repository"},{"url":"https://www.zora.uzh.ch/228400","host_type":"repository"}],"fields_of_study":["Circadian rhythm and melatonin","Genetics, Aging, and Longevity in Model Organisms","Chemical Reactions and Isotopes"],"mesh_terms":[],"keywords":["Chronotherapy (sleep phase)","Chronobiology","Circadian rhythm","Circadian clock","Temozolomide","Biology","Biological clock","Neuroscience","CLOCK","Bioinformatics","Physiology","Computational biology","Cancer research","Glioma"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Zero hunger"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-06T12:24:49.159051Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}