{"doi":"10.1093/neuonc/noac102","title":"Leveraging epigenomic patterns to resolve the heterogeneity and origins of CNS germ cell tumors","abstract":"Germ cell tumors (GCTs) are a heterogeneous group of tumors of germ cells, primarily occurring in gonads, however, about one-third of GCTs can also occur in extragonadal sites. Although significant strides have been made in studying this group of tumors, a clear understanding of the underlying molecular pathogenesis is still lacking. Central nervous system (CNS) GCTs are relatively rare tumors predominantly occurring in young and adolescent males, with a considerable geographical variation in incidence.1 CNS GCTs are classified into two major groups, germinomas and non-germinomatous germ cell tumors (NGGCTs). The latter is a heterogenous group consisting of subtypes, including yolk sac tumors, embryonal carcinomas, choriocarcinomas, and teratomas, often occurring as mixed GCTs. Germinomas account for up to ~65% of the CNS GCT and are extremely sensitive to chemotherapy and radiation.1 In contrast, NGGCTs require intense chemotherapy and radiation, and sometimes surgical resection. Distinct epigenetic programs in these subgroups may underscore disparate molecular underpinnings, clinical outcomes, and response to therapy.","journal":"Neuro-Oncology","year":2022,"id":306954,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9578,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":32658,"name":"Stephen C. Mack","orcid":"0000-0001-9620-4742","position":1,"is_corresponding":false},{"id":240493,"name":"Srinidhi Varadharajan","orcid":"0000-0002-2033-0758","position":0,"is_corresponding":true}],"reference_count":16,"raw_metadata":null,"created_at":"2026-07-19T00:32:52.703737Z","pmid":"35436342","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}