{"doi":"10.1093/neuonc/noaa021","title":"Final report from Intergroup NCCTG 86-72-51 (Alliance): a phase III randomized clinical trial of high-dose versus low-dose radiation for adult low-grade glioma","abstract":"BACKGROUND: The optimal radiation dose for adult supratentorial low-grade glioma is unknown. The aim of this study was to provide a final update on oncologic and cognitive outcomes of high-dose versus low-dose radiation for low-grade glioma. METHODS: Between 1986 and 1994, 203 patients with supratentorial low-grade glioma were randomized (1:1) to 50.4 Gy in 28 fractions versus 64.8 Gy in 36 fractions after any degree of resection. RESULTS: For all patients, median overall survival (OS) was 8.4 years (95% CI: 7.2-10.8). Median progression-free survival (PFS) was 5.2 years (95% CI: 4.3-6.6). Median follow-up is 17.2 years for the 33 patients still alive. High-dose radiation did not improve 15-year OS (22.4%) versus low-dose radiation (24.9%, log-rank P = 0.978) or 15-year PFS (high dose, 15.2% vs low dose, 9.5%; P = 0.7142). OS was significantly better for patients with preoperative tumor diameter <5 cm and baseline Mini-Mental State Examination (MMSE) >27 and who underwent gross total resection. PFS was improved for patients with oligodendroglioma versus astrocytoma, preoperative tumor diameter <5 cm, patients who had gross total resection, and patients with baseline MMSE >27. For patients who had normal MMSE at baseline, at 7 years only 1 patient (5%) had a clinically significant decrease in MMSE from the previous time point, with the remainder (95%) stable. None had decrease in MMSE at 10, 12, or 15 years. CONCLUSIONS: Long-term follow-up indicates no benefit to high-dose over low-dose radiation for low-grade gliomas. Cognitive function appeared to be stable after radiation as measured by MMSE.","journal":"Neuro-Oncology","year":2020,"id":60894,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":59,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.6748,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":273498,"name":"S. Keith Anderson","orcid":"0000-0003-1542-9726","position":1,"is_corresponding":false},{"id":322216,"name":"Xiomara W. Carrero","orcid":null,"position":2,"is_corresponding":false},{"id":259416,"name":"Paul D. Brown","orcid":"0000-0003-0022-4533","position":3,"is_corresponding":false},{"id":259331,"name":"Karla V. Ballman","orcid":"0000-0002-4492-0357","position":4,"is_corresponding":false},{"id":13875,"name":"Brian Patrick O’Neill","orcid":"0000-0001-7456-6152","position":5,"is_corresponding":false},{"id":236224,"name":"Walter J. Curran","orcid":"0000-0002-7552-4453","position":6,"is_corresponding":false},{"id":322217,"name":"Ross A. Abrams","orcid":null,"position":7,"is_corresponding":false},{"id":322218,"name":"Nadia N. Laack","orcid":null,"position":8,"is_corresponding":false},{"id":322219,"name":"Ralph Levitt","orcid":null,"position":9,"is_corresponding":false},{"id":247463,"name":"Evanthia Galanis","orcid":"0000-0001-8014-786X","position":10,"is_corresponding":false},{"id":321366,"name":"Jan C. Buckner","orcid":"0000-0002-8688-266X","position":11,"is_corresponding":false},{"id":322220,"name":"Edward G. Shaw","orcid":null,"position":12,"is_corresponding":false},{"id":321365,"name":"William G. Breen","orcid":"0000-0001-8039-2398","position":0,"is_corresponding":true}],"reference_count":15,"raw_metadata":null,"created_at":"2026-07-18T21:09:05.493770Z","pmid":"32002556","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}