{"doi":"10.1093/ndt/gfaa372","title":"Clinical features of acute kidney injury in patients receiving dabrafenib and trametinib","abstract":"BACKGROUND: Our objective was to characterize the incidence, risk factors and clinical features of acute kidney injury (AKI) in patients receiving dabrafenib and trametinib. METHODS: We performed a retrospective cohort study examining the kidney outcomes of patients in a large healthcare system who received dabrafenib/trametinib between 2010 and 2019. The primary outcome was AKI, defined as a 1.5-fold increase in serum creatinine from baseline within a 12-month study period. AKI severity and etiology was determined for each case by chart review. Logistic regression was used to evaluate baseline predictors of AKI. RESULTS: A total of 199 patients who received dabrafenib in our healthcare system from 2010 to 2019 were included in the analysis. Forty-two patients (21%) experienced AKI within 12 months; 10 patients (5% of the total cohort, 24% of AKI patients) experienced AKI occurring during a dabrafenib/trametinib-induced febrile syndrome characterized by fever, chills, gastrointestinal symptoms and elevated liver enzymes. Preexisting liver disease was the only significant predictor of AKI in the cohort. One patient had biopsy-proven granulomatous acute interstitial nephritis that resolved with corticosteroids. CONCLUSIONS: Oncologists and nephrologists should be aware that AKI is common after dabrafenib/trametinib and a substantial number of cases occur in the setting of treatment-induced pyrexia.","journal":"Nephrology Dialysis Transplantation","year":2020,"id":68837,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":22,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9099,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":321297,"name":"Meghan Lee","orcid":"0000-0002-6895-5968","position":1,"is_corresponding":false},{"id":268728,"name":"Ian A. Strohbehn","orcid":"0000-0003-2167-2896","position":2,"is_corresponding":false},{"id":364574,"name":"Orhan Efe","orcid":"0000-0003-4852-9061","position":3,"is_corresponding":false},{"id":322186,"name":"Nifasha Rusibamayila","orcid":null,"position":4,"is_corresponding":false},{"id":322187,"name":"Donald F. Chute","orcid":null,"position":5,"is_corresponding":false},{"id":237352,"name":"Robert B. Colvin","orcid":"0000-0002-4493-4150","position":6,"is_corresponding":false},{"id":364575,"name":"Ivy A. Rosales","orcid":"0000-0003-0621-3202","position":7,"is_corresponding":false},{"id":365632,"name":"Riley Fadden","orcid":null,"position":8,"is_corresponding":false},{"id":105169,"name":"Kerry L. Reynolds","orcid":"0000-0002-7793-654X","position":9,"is_corresponding":false},{"id":412,"name":"Ryan J. Sullivan","orcid":"0000-0001-5344-6645","position":10,"is_corresponding":false},{"id":364576,"name":"Howard L. Kaufman","orcid":"0000-0003-1131-004X","position":11,"is_corresponding":false},{"id":263650,"name":"Kenar D. Jhaveri","orcid":"0000-0003-1578-0524","position":12,"is_corresponding":false},{"id":263649,"name":"Meghan E. Sise","orcid":"0000-0002-4327-9713","position":13,"is_corresponding":false},{"id":268727,"name":"Harish Seethapathy","orcid":"0000-0002-1171-1022","position":0,"is_corresponding":true}],"reference_count":37,"raw_metadata":null,"created_at":"2026-07-18T21:41:52.279368Z","pmid":"33355659","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}