{"doi":"10.1093/ndt/gfaa208","title":"Urinary excretion of epidermal growth factor and rapid loss of kidney function","abstract":"BACKGROUND: Lower urinary excretion of the kidney tubule-specific biomarker epidermal growth factor (uEGF) is associated with increased risk of renal function [glomerular filtration rate (GFR)] loss in diabetes and in patients with established chronic kidney disease (CKD). We investigated whether uEGF is associated with rapid GFR decline or incident CKD in the general population. METHODS: Subjects without CKD or diabetes were recruited from the general population in Tromso, Norway [Renal Iohexol Clearance Survey (RENIS); N = 1249] and Groningen, the Netherlands [Prevention of REnal and Vascular END-stage disease (PREVEND); N = 4534], with a median follow-up of 5.6 and 7.4 years, respectively. GFR was measured by iohexol clearance in the RENIS and estimated using the CKD Epidemiology Collaboration creatinine-cystatin C equation in the PREVEND study. Rapid GFR decline was defined as an annual GFR loss >3.0 mL/min/1.73 m2 and in sensitivity analyses as subjects with the 10% steepest GFR slope within each cohort. RESULTS: Lower baseline uEGF excretion was associated with rapid GFR loss in both cohorts {RENIS, odds ratio [OR] per 1 μg/mmol lower uEGF 1.42 [95% confidence interval (CI) 1.06-1.91], P = 0.02; PREVEND, OR 1.29 [95% CI 1.10-1.53], P < 0.01}, adjusted for baseline GFR, albumin:creatinine ratio and conventional CKD risk factors. Similar results were obtained using the outcome of the 10% steepest GFR slope in each cohort. Lower uEGF levels were associated with incident CKD in the combined analysis of both cohorts. CONCLUSIONS: Lower uEGF levels are associated with increased risk of rapid GFR loss and incident CKD in the general population. This finding, together with previous findings in CKD and high-risk populations, supports that uEGF may serve as a broadly applicable biomarker representing the tubular component of the current glomerulus-centric clinical risk assessment system.","journal":"Nephrology Dialysis Transplantation","year":2020,"id":63235,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":46,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9655,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":334437,"name":"Laura R. Harskamp","orcid":"0000-0001-5490-8266","position":1,"is_corresponding":false},{"id":29419,"name":"Viji Nair","orcid":"0000-0003-1657-954X","position":2,"is_corresponding":false},{"id":334438,"name":"Kerby Shedden","orcid":"0000-0001-7222-6664","position":3,"is_corresponding":false},{"id":267824,"name":"Marit D. Solbu","orcid":"0000-0002-4331-7548","position":4,"is_corresponding":false},{"id":267817,"name":"Björn O. Eriksen","orcid":"0000-0002-5837-2806","position":5,"is_corresponding":false},{"id":5968,"name":"Matthias Kretzler","orcid":"0000-0003-4064-0582","position":6,"is_corresponding":false},{"id":21877,"name":"Ron T. Gansevoort","orcid":"0000-0002-3223-0906","position":7,"is_corresponding":false},{"id":5964,"name":"Wenjun Ju","orcid":"0000-0002-9136-8454","position":8,"is_corresponding":false},{"id":267820,"name":"Toralf Melsom","orcid":"0000-0003-0764-4813","position":9,"is_corresponding":false},{"id":334436,"name":"Jon Viljar Norvik","orcid":"0000-0001-7131-0418","position":0,"is_corresponding":true}],"reference_count":49,"raw_metadata":null,"created_at":"2026-07-18T21:11:00.632961Z","pmid":"33068410","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}