{"doi":"10.1093/nass/nrn093","title":"NMR assignments and the identification of the secondary structure of the anti-retroviral cytidine deaminase","abstract":null,"journal":"Nucleic Acids Symposium Series","year":2008,"id":625296,"datarank":0.20794415416798362,"base_score":1.3862943611198906,"endowment":1.3862943611198906,"self_citation_contribution":0.20794415416798362,"citation_network_contribution":0.0,"self_endowment_contribution":0.20794415416798362,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1616893,"name":"T. Nagata","orcid":null,"position":1,"is_corresponding":false},{"id":173619,"name":"Y. Habu","orcid":null,"position":2,"is_corresponding":false},{"id":1616894,"name":"R. Sugiyama","orcid":null,"position":3,"is_corresponding":false},{"id":1616895,"name":"F. Hayashi","orcid":null,"position":4,"is_corresponding":false},{"id":1616896,"name":"S. Yokoyama","orcid":null,"position":5,"is_corresponding":false},{"id":1616897,"name":"H. Takaku","orcid":null,"position":6,"is_corresponding":false},{"id":1616898,"name":"M. Katahira","orcid":null,"position":7,"is_corresponding":false},{"id":1616892,"name":"A. Furukawa","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"NMR assignments and the identification of the secondary structure of the anti-retroviral cytidine deaminase","abstract":"APOBEC3G (apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3G) is known to have a role in intrinsic cellular immunity against human immunodeficiency virus type1 (HIV-1). The antiretroviral activity of APOBEC3G (APO3G) is associated with the hypermutation of viral DNA through cytidine deamination. APO3G contains two cytidine deaminase domains that are characterised by highly conserved zinc-coordinating motif. It is known that only the C-terminal domain of APO3G (c-APO3G) has the catalytic activity. To shed light on the molecular mechanism of action by which APO3G inactivates HIV-1, we have undertaken the structural and binding studies by NMR. Here, we show the achievement of backbone assignments of c-APO3G and the identification of the secondary structure deduced from chemical shift index (CSI) and NOE data.","is_dataset_classified":null,"base_score":1.3862943611198906,"endowment":1.3862943611198906,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"18776314","pmcid":null,"openalex_id":"https://openalex.org/W2158705512","authors":[],"funders":[],"total_grants":0,"fwci":4.2321,"citation_percentile":0.93589744,"influential_citations":0,"citation_trend":[],"oa_status":"bronze","license":null,"oa_locations":[{"url":"https://academic.oup.com/nass/article-pdf/52/1/183/3864171/nrn093.pdf","host_type":"journal"},{"url":"https://academic.oup.com/nass/article-pdf/52/1/183/3864171/nrn093.pdf","host_type":"publisher"},{"url":"http://academic.oup.com/nass/article-pdf/52/1/183/3864171/nrn093.pdf","host_type":"publisher"},{"url":"https://doi.org/10.1093/nass/nrn093","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/18776314","host_type":"repository"}],"fields_of_study":["HIV Research and Treatment","HIV/AIDS drug development and treatment","Protein Structure and Dynamics","APOBEC-3G Deaminase","Cytidine Deaminase","Humans","Nuclear Magnetic Resonance, Biomolecular","Protein Structure, Secondary","Structural Homology, Protein"],"mesh_terms":["APOBEC-3G Deaminase","Cytidine Deaminase","Humans","Protein Structure, Secondary","Nuclear Magnetic Resonance, Biomolecular","Structural Homology, Protein"],"keywords":["Cytidine deaminase","APOBEC3G","Cytidine","Somatic hypermutation","Protein secondary structure","Activation-induced (cytidine) deaminase","Chemistry","Biology","Enzyme","Biochemistry","Molecular biology","Computational biology","Virology","Genetics","Antibody"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-04T06:22:01.892158Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}