{"doi":"10.1093/nar/gkw1304","title":"ADAR2 regulates RNA stability by modifying access of decay-promoting RNA-binding proteins","abstract":null,"journal":"Nucleic Acids Research","year":2017,"id":590405,"datarank":2.025549196476332,"base_score":3.9318256327243257,"endowment":3.9318256327243257,"self_citation_contribution":0.5897738449086489,"citation_network_contribution":1.4357753515676828,"self_endowment_contribution":0.5897738449086489,"citer_contribution":1.4357753515676828,"corpus_percentile":null,"corpus_rank":null,"citation_count":50,"citer_count":44,"citers_with_citation_signal":41,"citers_with_endowment":41,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":377533,"name":"Vidisha Tripathi","orcid":null,"position":1,"is_corresponding":false},{"id":633017,"name":"Abid Khan","orcid":"0000-0003-0968-8705","position":2,"is_corresponding":false},{"id":1510612,"name":"Je-Hyun Yoon","orcid":null,"position":3,"is_corresponding":false},{"id":1510613,"name":"Deepak K. Singh","orcid":null,"position":4,"is_corresponding":false},{"id":550187,"name":"Omid Gholamalamdari","orcid":"0000-0002-5773-1205","position":5,"is_corresponding":false},{"id":1510614,"name":"Shuomeng Guang","orcid":null,"position":6,"is_corresponding":false},{"id":1510615,"name":"Johan Ohlson","orcid":null,"position":7,"is_corresponding":false},{"id":1510616,"name":"Helene Wahlstedt","orcid":null,"position":8,"is_corresponding":false},{"id":1510617,"name":"Marie Öhman","orcid":null,"position":9,"is_corresponding":false},{"id":809033,"name":"Michael F. Jantsch","orcid":"0000-0003-1747-0853","position":10,"is_corresponding":false},{"id":573753,"name":"Nicholas K. Conrad","orcid":"0000-0002-8562-0895","position":11,"is_corresponding":false},{"id":51348,"name":"Jian Ma","orcid":"0000-0002-4202-5834","position":12,"is_corresponding":false},{"id":218108,"name":"Myriam Gorospe","orcid":"0000-0001-5439-3434","position":13,"is_corresponding":false},{"id":376030,"name":"Supriya G. Prasanth","orcid":"0000-0002-3735-7498","position":14,"is_corresponding":false},{"id":276013,"name":"Kannanganattu V. Prasanth","orcid":"0000-0003-4587-8362","position":15,"is_corresponding":false},{"id":1061151,"name":"Aparna Anantharaman","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"ADAR2 regulates RNA stability by modifying access of decay-promoting RNA-binding proteins","abstract":"Adenosine deaminases acting on RNA (ADARs) catalyze the editing of adenosine residues to inosine (A-to-I) within RNA sequences, mostly in the introns and UTRs (un-translated regions). The significance of editing within non-coding regions of RNA is poorly understood. Here, we demonstrate that association of ADAR2 with RNA stabilizes a subset of transcripts. ADAR2 interacts with and edits the 3΄UTR of nuclear-retained Cat2 transcribed nuclear RNA (Ctn RNA). In absence of ADAR2, the abundance and half-life of Ctn RNA are significantly reduced. Furthermore, ADAR2-mediated stabilization of Ctn RNA occurred in an editing-independent manner. Unedited Ctn RNA shows enhanced interaction with the RNA-binding proteins HuR and PARN [Poly(A) specific ribonuclease deadenylase]. HuR and PARN destabilize Ctn RNA in absence of ADAR2, indicating that ADAR2 stabilizes Ctn RNA by antagonizing its degradation by PARN and HuR. Transcriptomic analysis identified other RNAs that are regulated by a similar mechanism. In summary, we identify a regulatory mechanism whereby ADAR2 enhances target RNA stability by limiting the interaction of RNA-destabilizing proteins with their cognate substrates.","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"28053121","pmcid":"PMC5397167","openalex_id":null,"authors":[],"funders":[{"funder_name":"NIGMS NIH HHS","grant_id":"R01 GM099669","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"R01 GM088252","title":null},{"funder_name":"National Institutes of Health","grant_id":"1Z01AG000511-11","title":"Post-transcriptional Regulation Of Proliferative and Stress Response Genes"},{"funder_name":"National Institutes of Health","grant_id":"1Z01AG000511-10","title":"Posttranscriptional Regulation Of Genes Controling Cell Growth And Proliferation"},{"funder_name":"National Science Foundation","grant_id":"1243372","title":"CAREER: Establishment of Replication Timing and Patterning in Mammalian Cells"},{"funder_name":"National Institutes of Health","grant_id":"5R01GM088252-04","title":"Characterization of nuclear retained RNA-mediated gene regulatory mechanism"}],"total_grants":6,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":"gold","license":"cc-by-nc","oa_locations":[{"url":"https://academic.oup.com/nar/article-pdf/45/7/4189/16965510/gkw1304.pdf","host_type":"publisher"},{"url":"https://europepmc.org/articles/PMC5397167","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC5397167?pdf=render","host_type":"Europe_PMC"},{"url":"https://doi.org/10.1093/nar/gkw1304","host_type":""},{"url":"https://pubmed.ncbi.nlm.nih.gov/28053121","host_type":""},{"url":"http://dx.doi.org/10.1093/nar/gkw1304","host_type":""},{"url":"https://dx.doi.org/10.1093/nar/gkw1304","host_type":""}],"fields_of_study":["0301 basic medicine","03 medical and health sciences"],"mesh_terms":["Animals","Mice","Adenosine Deaminase","Exoribonucleases","Cationic Amino Acid Transporter 2","RNA-Binding Proteins","3' Untranslated Regions","RNA Editing","RNA Stability","RNA, Long Noncoding","ELAV-Like Protein 1"],"keywords":["Adenosine Deaminase","RNA Stability","RNA-Binding Proteins","ELAV-Like Protein 1","Mice","Exoribonucleases","RNA","Animals","RNA, Long Noncoding","RNA Editing","Cationic Amino Acid Transporter 2","3' Untranslated Regions"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-24T20:06:12.904947Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}