{"doi":"10.1093/nar/gku1011","title":"Disease Ontology 2015 update: an expanded and updated database of human diseases for linking biomedical knowledge through disease data","abstract":null,"journal":"Nucleic Acids Research","year":2015,"id":599073,"datarank":0.9634870445300281,"base_score":6.423246963533519,"endowment":6.423246963533519,"self_citation_contribution":0.9634870445300281,"citation_network_contribution":0.0,"self_endowment_contribution":0.9634870445300281,"citer_contribution":0.0,"corpus_percentile":79.0,"corpus_rank":2749,"citation_count":615,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":true,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":29041,"name":"Cesar Arze","orcid":"0000-0002-3606-4183","position":1,"is_corresponding":false},{"id":482466,"name":"Victor Felix","orcid":"0000-0002-9773-0629","position":2,"is_corresponding":false},{"id":1535387,"name":"Elvira Mitraka","orcid":null,"position":3,"is_corresponding":false},{"id":1535388,"name":"Evan Bolton","orcid":null,"position":4,"is_corresponding":false},{"id":786731,"name":"Gang Fu","orcid":"0000-0003-4081-5696","position":5,"is_corresponding":false},{"id":6476,"name":"Christopher J. Mungall","orcid":"0000-0002-6601-2165","position":6,"is_corresponding":false},{"id":1535389,"name":"Janos X. Binder","orcid":null,"position":7,"is_corresponding":false},{"id":19113,"name":"James Malone","orcid":"0000-0002-1615-2899","position":8,"is_corresponding":false},{"id":586,"name":"Drashtti Vasant","orcid":"0000-0002-2402-351X","position":9,"is_corresponding":false},{"id":2833,"name":"Helen Parkinson","orcid":"0000-0003-3035-4195","position":10,"is_corresponding":false},{"id":19861,"name":"Lynn M. Schriml","orcid":"0000-0001-8910-9851","position":11,"is_corresponding":false},{"id":85421,"name":"Warren A. Kibbe","orcid":"0000-0001-5622-7659","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Disease Ontology 2015 update: an expanded and updated database of human diseases for linking biomedical knowledge through disease data","abstract":"The current version of the Human Disease Ontology (DO) (http://www.disease-ontology.org) database expands the utility of the ontology for the examination and comparison of genetic variation, phenotype, protein, drug and epitope data through the lens of human disease. DO is a biomedical resource of standardized common and rare disease concepts with stable identifiers organized by disease etiology. The content of DO has had 192 revisions since 2012, including the addition of 760 terms. Thirty-two percent of all terms now include definitions. DO has expanded the number and diversity of research communities and community members by 50+ during the past two years. These community members actively submit term requests, coordinate biomedical resource disease representation and provide expert curation guidance. Since the DO 2012 NAR paper, there have been hundreds of term requests and a steady increase in the number of DO listserv members, twitter followers and DO website usage. DO is moving to a multi-editor model utilizing Protégé to curate DO in web ontology language. This will enable closer collaboration with the Human Phenotype Ontology, EBI's Ontology Working Group, Mouse Genome Informatics and the Monarch Initiative among others, and enhance DO's current asserted view and multiple inferred views through reasoning.","is_dataset_classified":null,"base_score":6.423246963533519,"endowment":6.423246963533519,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"25348409","pmcid":"PMC4383880","openalex_id":"https://openalex.org/W2124045889","authors":[],"funders":[{"funder_name":"NCRR NIH HHS","grant_id":"R01RR025341","title":null},{"funder_name":"NIH HHS","grant_id":"R24 OD011883","title":null},{"funder_name":"Wellcome Trust","grant_id":"098503/D/12/Z","title":null},{"funder_name":"NHGRI NIH HHS","grant_id":"U54-HG004028","title":null},{"funder_name":"Wellcome Trust","grant_id":"unidentified","title":"unidentified"},{"funder_name":"National Institutes of Health","grant_id":"5R24OD011883-07","title":"The Monarch Initiative: Linking Diseases to Model Organism Resources"},{"funder_name":"National Institutes of Health","grant_id":"2U54HG004028-06","title":"Core 5"},{"funder_name":"National Institutes of Health","grant_id":"5R21RR025341-02","title":"Combined ultrahigh-resolution optical tweezers and single-molecule fluorescence"}],"total_grants":8,"fwci":22.3552,"citation_percentile":0.99740869,"influential_citations":0,"citation_trend":[{"year":2013,"count":1},{"year":2015,"count":32},{"year":2016,"count":59},{"year":2017,"count":81},{"year":2018,"count":113},{"year":2019,"count":101},{"year":2020,"count":74},{"year":2021,"count":46},{"year":2022,"count":33},{"year":2023,"count":23},{"year":2024,"count":26},{"year":2025,"count":19},{"year":2026,"count":7}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://academic.oup.com/nar/article-pdf/43/D1/D1071/17435884/gku1011.pdf","host_type":"journal"},{"url":"https://academic.oup.com/nar/article-pdf/43/D1/D1071/17435884/gku1011.pdf","host_type":"publisher"},{"url":"http://academic.oup.com/nar/article-pdf/43/D1/D1071/17435884/gku1011.pdf","host_type":"publisher"},{"url":"https://doi.org/10.1093/nar/gku1011","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/25348409","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4383880","host_type":"repository"},{"url":"https://www.osti.gov/biblio/1256071","host_type":"repository"},{"url":"http://orbilu.uni.lu/handle/10993/26365","host_type":"repository"},{"url":"https://www.osti.gov/servlets/purl/1256071","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC4383880","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC4383880?pdf=render","host_type":"Europe_PMC"},{"url":"http://dx.doi.org/10.1093/nar/gku1011","host_type":""},{"url":"https://dx.doi.org/10.1093/nar/gku1011","host_type":""},{"url":"https://orbilu.uni.lu/handle/10993/26365","host_type":""}],"fields_of_study":["Biomedical Text Mining and Ontologies","Genomics and Rare Diseases","Bioinformatics and Genomic Networks","0301 basic medicine","0303 health sciences","03 medical and health sciences","Biological Ontologies","Databases, Factual","Disease","Genetic Diseases, Inborn","Humans","Internet","Rare Diseases"],"mesh_terms":["Disease","Humans","Databases, Factual","Internet","Genetic Diseases, Inborn","Rare Diseases","Biological Ontologies"],"keywords":["Ontology","Identifier","Disease","Ontology-based data integration","Resource (disambiguation)","Annotation","Computer science","World Wide Web","Biology","Database","Data science","Bioinformatics","Semantic Web","Medicine","Internet","Databases, Factual","Genetic Diseases, Inborn","Life sciences","Rare Diseases/genetics","Rare Diseases","Biological Ontologies","Sciences du vivant","Database Issue","Humans"],"sdg_mappings":[{"sdg_number":3,"sdg_label":"3. Good health"},{"sdg_number":0,"sdg_label":"Partnerships for the goals"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-28T17:46:00.435255Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}