{"doi":"10.1093/nar/gkq1037","title":"PROMISCUOUS: a database for network-based drug-repositioning","abstract":"The procedure of drug approval is time-consuming, costly and risky. Accidental findings regarding multi-specificity of approved drugs led to block-busters in new indication areas. Therefore, the interest in systematically elucidating new areas of application for known drugs is rising. Furthermore, the knowledge, understanding and prediction of so-called off-target effects allow a rational approach to the understanding of side-effects. With PROMISCUOUS we provide an exhaustive set of drugs (25,000), including withdrawn or experimental drugs, annotated with drug-protein and protein-protein relationships (21,500/104,000) compiled from public resources via text and data mining including manual curation. Measures of structural similarity for drugs as well as known side-effects can be easily connected to protein-protein interactions to establish and analyse networks responsible for multi-pharmacology. This network-based approach can provide a starting point for drug-repositioning. PROMISCUOUS is publicly available at http://bioinformatics.charite.de/promiscuous.","journal":"Nucleic Acids Research","year":2010,"id":9053,"datarank":9.827166798399594,"base_score":5.424950017481403,"endowment":5.424950017481403,"self_citation_contribution":0.8137425026222106,"citation_network_contribution":9.013424295777384,"self_endowment_contribution":0.8137425026222106,"citer_contribution":9.013424295777384,"corpus_percentile":78.43775427176567,"corpus_rank":266,"citation_count":227,"citer_count":194,"citers_with_citation_signal":194,"citers_with_endowment":194,"datacite_reuse_total":0,"is_dataset":true,"is_dataset_confidence":0.669,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2010-11-10","algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":77859,"name":"M. S. Murgueitio","orcid":null,"position":1,"is_corresponding":false},{"id":72377,"name":"M. Dunkel","orcid":null,"position":2,"is_corresponding":false},{"id":77860,"name":"S. Koerner","orcid":null,"position":3,"is_corresponding":false},{"id":36162,"name":"Joachim von Eichborn","orcid":null,"position":6,"is_corresponding":false},{"id":77861,"name":"Manuela S. Murgueitio","orcid":null,"position":7,"is_corresponding":false},{"id":72388,"name":"Mathias Dunkel","orcid":"0000-0002-6642-483X","position":8,"is_corresponding":false},{"id":125,"name":"Philip  E. Bourne","orcid":"0000-0002-7618-7292","position":9,"is_corresponding":false},{"id":3311,"name":"Robert Preissner","orcid":"0000-0002-2407-1087","position":10,"is_corresponding":false}],"reference_count":28,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-03-01T18:20:47.508186Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}