{"doi":"10.1093/nar/gkm569","title":"Tissue-specific splicing regulator Fox-1 induces exon skipping by interfering E complex formation on the downstream intron of human F1  gene","abstract":null,"journal":"Nucleic Acids Research","year":2007,"id":641497,"datarank":0.5709993734655481,"base_score":3.8066624897703196,"endowment":3.8066624897703196,"self_citation_contribution":0.5709993734655481,"citation_network_contribution":0.0,"self_endowment_contribution":0.5709993734655481,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":44,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1596724,"name":"A. Kato","orcid":null,"position":1,"is_corresponding":false},{"id":1144435,"name":"Y. Jin","orcid":"0000-0002-7323-0830","position":2,"is_corresponding":false},{"id":1667985,"name":"T. Ideue","orcid":null,"position":3,"is_corresponding":false},{"id":136846,"name":"T. Hirose","orcid":null,"position":4,"is_corresponding":false},{"id":176004,"name":"N. Kataoka","orcid":null,"position":5,"is_corresponding":false},{"id":1527545,"name":"T. Fujiwara","orcid":null,"position":6,"is_corresponding":false},{"id":10108,"name":"H. Sakamoto","orcid":"0000-0001-6819-2238","position":7,"is_corresponding":false},{"id":155809,"name":"K. Inoue","orcid":null,"position":8,"is_corresponding":false},{"id":1667984,"name":"K. Fukumura","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Tissue-specific splicing regulator Fox-1 induces exon skipping by interfering E complex formation on the downstream intron of human F1  gene","abstract":"Fox-1 is a regulator of tissue-specific splicing, via binding to the element (U)GCAUG in mRNA precursors, in muscles and neuronal cells. Fox-1 can regulate splicing positively or negatively, most likely depending on where it binds relative to the regulated exon. In cases where the (U)GCAUG element lies in an intron upstream of the alternative exon, Fox-1 protein functions as a splicing repressor to induce exon skipping. Here we report the mechanism of exon skipping regulated by Fox-1, using the hF1gamma gene as a model system. We found that Fox-1 induces exon 9 skipping by repressing splicing of the downstream intron 9 via binding to the GCAUG repressor elements located in the upstream intron 8. In vitro splicing analyses showed that Fox-1 prevents formation of the pre-spliceosomal early (E) complex on intron 9. In addition, we located a region of the Fox-1 protein that is required for inducing exon skipping. Taken together, our data show a novel mechanism of how RNA-binding proteins regulate alternative splicing.","is_dataset_classified":null,"base_score":3.8066624897703196,"endowment":3.8066624897703196,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"17686786","pmcid":"PMC2018636","openalex_id":"https://openalex.org/W2096708722","authors":[],"funders":[],"total_grants":0,"fwci":1.5097,"citation_percentile":0.8141786,"influential_citations":0,"citation_trend":[{"year":2012,"count":3},{"year":2013,"count":6},{"year":2014,"count":4},{"year":2015,"count":1},{"year":2016,"count":5},{"year":2017,"count":1},{"year":2018,"count":2},{"year":2021,"count":3},{"year":2022,"count":1},{"year":2023,"count":1},{"year":2024,"count":1},{"year":2025,"count":1}],"oa_status":"gold","license":"cc-by-nc","oa_locations":[{"url":"https://academic.oup.com/nar/article-pdf/35/16/5303/4108943/gkm569.pdf","host_type":"journal"},{"url":"https://academic.oup.com/nar/article-pdf/35/16/5303/4108943/gkm569.pdf","host_type":"publisher"},{"url":"http://academic.oup.com/nar/article-pdf/35/16/5303/4108943/gkm569.pdf","host_type":"publisher"},{"url":"https://doi.org/10.1093/nar/gkm569","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/17686786","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2018636","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC2018636","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC2018636?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["RNA Research and Splicing","RNA modifications and cancer","RNA and protein synthesis mechanisms"],"mesh_terms":["RNA Splicing Factors","Animals","Binding Sites","Cell Line","Exons","Proton-Translocating ATPases","Humans","Introns","Muscles","Regulatory Sequences, Nucleic Acid","Repressor Proteins","RNA Precursors","RNA, Messenger","RNA-Binding Proteins","Spliceosomes","Alternative Splicing","Protein Structure, Tertiary","Mice"],"keywords":["Intron","Exon","RNA splicing","Biology","Exon skipping","Minigene","Alternative splicing","Exonic splicing enhancer","Repressor","Genetics","Gene","Cell biology","Molecular biology","RNA","Gene expression"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-07T18:26:00.160520Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}