{"doi":"10.1093/nar/gkaf838","title":"IVCDB: a comprehensive database of iridoviruses for epidemiology, genetic evolution, and disease management","abstract":"<jats:title>Abstract</jats:title>\n                  <jats:p>Iridoviruses, a globally distributed group of double-stranded DNA viruses, exhibit remarkable environmental adaptability and host-switching capabilities, infecting over 200 species of ectothermic vertebrates and invertebrates, including reptiles, amphibians, fish, crustaceans, and insects. These characteristics have led to substantial economic losses in global aquaculture and population declines in amphibian and invertebrate species. Despite accumulating genomic data, research progress remains constrained by three critical limitations: fragmented multidimensional data resources, ambiguous taxonomic levels, and insufficient spatiotemporal visualization tools. To address these challenges, we present the Iridovirus Comprehensive Database (IVCDB; https://www.iridovirus.com/), a comprehensive database consolidating multidimensional iridovirus-related data. IVCDB provides curated comprehensive information on 310 geographically distinct virus isolates complemented by an interactive geospatial visualization system and a nonredundant protein database containing 4378 viral proteins, including 162 core genes/proteins, derived from a standardized genome annotation pipeline. This database also contains phylogenetic relationships across various viral taxonomic levels within the family Iridoviridaeanda viral genome collinearity analysis tool, facilitating taxonomic analysis and supporting novel species identification. Furthermore, IVCDB integrates an application-oriented knowledge base including host range data, experimentally validated vaccines, and field-deployable visual detection methods. IVCDB offers substantial support for disease control and host conservation while addressing systemic bottlenecks in viral cross-species transmission research.</jats:p>","journal":"Nucleic Acids Research","year":2026,"id":653338,"datarank":0.10397207708399181,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"self_citation_contribution":0.10397207708399181,"citation_network_contribution":0.0,"self_endowment_contribution":0.10397207708399181,"citer_contribution":0.0,"corpus_percentile":21.9,"corpus_rank":9921,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":true,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1704686,"name":"Weiqiang Pan","orcid":null,"position":1,"is_corresponding":false},{"id":1704687,"name":"Zhengqi Feng","orcid":null,"position":2,"is_corresponding":false},{"id":1704688,"name":"Yangchi Cui","orcid":null,"position":3,"is_corresponding":false},{"id":1704689,"name":"Hualong Su","orcid":null,"position":4,"is_corresponding":false},{"id":1704690,"name":"Changjun Guo","orcid":"0000-0003-3223-6176","position":5,"is_corresponding":false},{"id":1704691,"name":"Jianguo He","orcid":null,"position":6,"is_corresponding":false},{"id":1704685,"name":"Mincong Liang","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"IVCDB: a comprehensive database of iridoviruses for epidemiology, genetic evolution, and disease management","abstract":"<jats:title>Abstract</jats:title>\n                  <jats:p>Iridoviruses, a globally distributed group of double-stranded DNA viruses, exhibit remarkable environmental adaptability and host-switching capabilities, infecting over 200 species of ectothermic vertebrates and invertebrates, including reptiles, amphibians, fish, crustaceans, and insects. These characteristics have led to substantial economic losses in global aquaculture and population declines in amphibian and invertebrate species. Despite accumulating genomic data, research progress remains constrained by three critical limitations: fragmented multidimensional data resources, ambiguous taxonomic levels, and insufficient spatiotemporal visualization tools. To address these challenges, we present the Iridovirus Comprehensive Database (IVCDB; https://www.iridovirus.com/), a comprehensive database consolidating multidimensional iridovirus-related data. IVCDB provides curated comprehensive information on 310 geographically distinct virus isolates complemented by an interactive geospatial visualization system and a nonredundant protein database containing 4378 viral proteins, including 162 core genes/proteins, derived from a standardized genome annotation pipeline. This database also contains phylogenetic relationships across various viral taxonomic levels within the family Iridoviridaeanda viral genome collinearity analysis tool, facilitating taxonomic analysis and supporting novel species identification. Furthermore, IVCDB integrates an application-oriented knowledge base including host range data, experimentally validated vaccines, and field-deployable visual detection methods. IVCDB offers substantial support for disease control and host conservation while addressing systemic bottlenecks in viral cross-species transmission research.</jats:p>","is_dataset_classified":null,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"40874445","pmcid":"PMC12807783","openalex_id":"https://openalex.org/W4413773627","authors":[],"funders":[{"funder_name":"National Key Research and Development Program of China","grant_id":"2022YFE0203900","title":null},{"funder_name":"Earmarked Fund for China Agriculture Research System","grant_id":"CARS-46","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"32473201","title":null},{"funder_name":"Special Project for Research and Development in Key areas of Guangdong Province","grant_id":"2022B1111030001","title":null},{"funder_name":"Science and Technology Planning Project of Guangdong Province","grant_id":"2024B1212040007","title":null},{"funder_name":"Basic and Applied Basic Research Foundation of Guangdong Province","grant_id":"2023A1515110395","title":null}],"total_grants":6,"fwci":1.8309,"citation_percentile":0.86333435,"influential_citations":0,"citation_trend":[{"year":2026,"count":1}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://academic.oup.com/nar/advance-article-pdf/doi/10.1093/nar/gkaf838/64147265/gkaf838.pdf","host_type":"journal"},{"url":"https://academic.oup.com/nar/advance-article-pdf/doi/10.1093/nar/gkaf838/64147265/gkaf838.pdf","host_type":"publisher"},{"url":"https://academic.oup.com/nar/article-pdf/54/D1/D790/64147265/gkaf838.pdf","host_type":"publisher"},{"url":"https://doi.org/10.1093/nar/gkaf838","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/40874445","host_type":"repository"},{"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12807783/","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC12807783","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC12807783?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Plant Virus Research Studies","Bacteriophages and microbial interactions","Respiratory viral infections research"],"mesh_terms":["Animals","DNA Virus Infections","Phylogeny","Viral Proteins","Genome, Viral","Iridovirus","Evolution, Molecular","Databases, Genetic"],"keywords":["Biology","Disease management","Disease","Compendium","Epidemiology","MEDLINE","Data science","Computational biology","Database","Systematic review","Computer science","Pathology","History"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-10T20:58:32.431329Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}